Cell penetration: scope and limitations by the application of cell‐penetrating peptides

S Reissmann - Journal of Peptide Science, 2014 - Wiley Online Library
The penetration of polar or badly soluble compounds through a cell membrane into live cells
requires mechanical support or chemical helpers. Cell‐penetrating peptides (CPPs) are very …

Cell-penetrating peptides: design, synthesis, and applications

DM Copolovici, K Langel, E Eriste, U Langel - ACS nano, 2014 - ACS Publications
The intrinsic property of cell-penetrating peptides (CPPs) to deliver therapeutic molecules
(nucleic acids, drugs, imaging agents) to cells and tissues in a nontoxic manner has …

Mechanism matters: a taxonomy of cell penetrating peptides

WB Kauffman, T Fuselier, J He, WC Wimley - Trends in biochemical …, 2015 - cell.com
The permeability barrier imposed by cellular membranes limits the access of exogenous
compounds to the interior of cells. Researchers and patients alike would benefit from …

[HTML][HTML] Intracellular delivery of molecular cargo using cell-penetrating peptides and the combination strategies

H Li, TY Tsui, W Ma - International journal of molecular sciences, 2015 - mdpi.com
Cell-penetrating peptides (CPPs) can cross cellular membranes in a non-toxic fashion,
improving the intracellular delivery of various molecular cargos such as nanoparticles, small …

Cell-penetrating peptides transport therapeutics into cells

JD Ramsey, NH Flynn - Pharmacology & therapeutics, 2015 - Elsevier
Nearly 30 years ago, certain small, relatively nontoxic peptides were discovered to be
capable of traversing the cell membrane. These cell-penetrating peptides, as they are now …

Potential efficacy of cell-penetrating peptides for nucleic acid and drug delivery in cancer

A Bolhassani - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2011 - Elsevier
Cell penetrating peptides (CPPs) are short amphipathic and cationic peptides that are
rapidly internalized across cell membranes. They can be used to deliver molecular cargo …

Mechanisms of cellular uptake of cell‐penetrating peptides

F Madani, S Lindberg, Ü Langel, S Futaki… - Journal of …, 2011 - Wiley Online Library
Recently, much attention has been given to the problem of drug delivery through the cell‐
membrane in order to treat and manage several diseases. The discovery of cell penetrating …

[HTML][HTML] A novel cell-penetrating peptide, M918, for efficient delivery of proteins and peptide nucleic acids

S El-Andaloussi, HJ Johansson, T Holm, Ü Langel - Molecular Therapy, 2007 - cell.com
Cell-penetrating peptides (CPPs) have attracted increasing attention in the past decade as a
result of their high potential to convey various, otherwise impermeable, bioactive agents …

Cell penetrating peptides: efficient vectors for delivery of nanoparticles, nanocarriers, therapeutic and diagnostic molecules

SM Farkhani, A Valizadeh, H Karami, S Mohammadi… - Peptides, 2014 - Elsevier
Efficient delivery of therapeutic and diagnostic molecules to the cells and tissues is a difficult
challenge. The cellular membrane is very effective in its role as a selectively permeable …

Cell-penetrating peptides with intracellular organelle targeting

CP Cerrato, K Künnapuu, Ü Langel - Expert opinion on drug …, 2017 - Taylor & Francis
Introduction: One of the major limiting steps in order to have an effective drug is the passage
through one or more cell membranes to reach its site of action. To reach the action-site, the …