[HTML][HTML] Survival of NSCLC patients treated with cimavax-EGF as switch maintenance in the real-world scenario

YIF Vega, DLP González, SCA Sarmiento… - Journal of …, 2023 - ncbi.nlm.nih.gov
Abstract Introduction: In Cuba, lung cancer represents the first cause of mortality for both
sexes. Non-small cell lung cancer (NSCLC) is the most prevalent histology. Overall, 75-85 …

A phase III clinical trial of the epidermal growth factor vaccine CIMAvax-EGF as switch maintenance therapy in advanced non–small cell lung cancer patients

PC Rodriguez, X Popa, O Martínez, S Mendoza… - Clinical Cancer …, 2016 - AACR
Purpose: EGFR is a well-validated target for patients with non–small cell lung cancer
(NSCLC). CIMAvax-EGF is a therapeutic cancer vaccine composed of human recombinant …

Safety and effectiveness of CIMAvax-EGF administered in community polyclinics

RA Ortiz Carrodeguas, G Lorenzo Monteagudo… - Frontiers in …, 2024 - frontiersin.org
In spite of the advances in immunotherapy and targeted therapies, lung cancer continues to
be the leading cause of cancer-related death. The epidermal growth factor receptor is an …

CIMAvax-EGF, a therapeutic non-small cell lung cancer vaccine

M Tagliamento, E Rijavec, G Barletta… - Expert Opinion on …, 2018 - Taylor & Francis
Introduction: Lung cancer represents the most common cause of cancer death worldwide.
While the prognosis remains poor, immunotherapy is giving a positive impact on survival …

CIMAvax-EGF: a new therapeutic vaccine for advanced non-small cell lung cancer patients

D Saavedra, T Crombet - Frontiers in immunology, 2017 - frontiersin.org
Lung cancer is the common fatal illness with the highest incidence and mortality globally.
Epidermal growth factor receptor overexpression by tumor cells is associated with …

[HTML][HTML] CIMAvax-EGF: Toward long-term survival of advanced NSCLC

D Saavedra, E Neninger, C Rodriguez, C Viada… - Seminars in …, 2018 - Elsevier
Lung cancer remains one of the leading causes of cancer-related deaths. Non–small cell
lung cancer (NSCLC) is the most common histologic type of lung cancer. Medical and …

The position of EGF deprivation in the management of advanced Non-Small Cell Lung Cancer

T Crombet Ramos, O Santos Morales, GK Dy… - Frontiers in …, 2021 - frontiersin.org
Advanced non-small cell lung cancer (NSCLC) has faced a therapeutic revolution with the
advent of tyrosine kinase inhibitors (TKIs) and immune checkpoints inhibitors (ICIs) …

CIMAvax EGF (EGF-P64K) vaccine for the treatment of non-small-cell lung cancer

T Crombet Ramos, PC Rodríguez… - Expert review of …, 2015 - Taylor & Francis
Epidermal growth factor receptor (EGFR) is overexpressed in many epithelial tumors and its
role in the development of non-small-cell lung cancer (NSCLC) is widely documented …

[HTML][HTML] Clinical development and perspectives of CIMAvax EGF, Cuban vaccine for non-small-cell lung cancer therapy

PC Rodríguez, G Rodríguez, G González… - MEDICC review, 2010 - medigraphic.com
Introduction CIMAvax EGF is a therapeutic anticancer vaccine developed entirely in Cuba
and licensed in Cuba for use in adult patients with stage IIIB/IV non-small-cell lung cancer …

Augmenting antibody response to EGF-depleting immunotherapy: Findings from a phase I trial of CIMAvax-EGF in combination with nivolumab in advanced stage …

R Evans, K Lee, PK Wallace, M Reid, J Muhitch… - Frontiers in …, 2022 - frontiersin.org
Background CIMAvax-EGF is an epidermal growth factor (EGF)-depleting immunotherapy
which has shown survival benefit as a switch maintenance treatment after platinum-based …