Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of
the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of …

Hypoxia or oxygen deficiency is a salient feature of solid tumors. Hypoxic tumors are often
resistant to conventional cancer therapies, and tumor hypoxia correlates with advanced …

Solid tumors often contain regions with insufficient oxygen delivery, a condition called
hypoxia. Tumor hypoxia is an independent prognostic factor significantly correlated with …

Spontaneous tumors often contain heterogeneous populations of tumor cells with different
tumor-initiating potentials or cancer cell “stemness.” Clonal heterogeneity can be traced to …

Hypoxia is an important feature of the tumor microenvironment, and is closely associated
with cell proliferation, angiogenesis, metabolism and the tumor immune response. All these …

Tumors are often viewed as unique entities with specific behaviors. However, tumors are a
mixture of differentially evolved subpopulations of cells in constant Darwinian evolution …

Hypoxia is a persistent physiological feature of many different solid tumors and a key driver
of malignancy, and in recent years, it has been recognized as an important target for cancer …

Diminished oxygen availability, termed hypoxia, within solid tumors is one of the most
common characteristics of cancer. Hypoxia shapes the landscape of the tumor …

Having a hypoxic microenvironment is a common and salient feature of most solid tumors.
Hypoxia has a profound effect on the biological behavior and malignant phenotype of …

Hypoxia or low oxygen concentration in tumor microenvironment has widespread effects
ranging from altered angiogenesis and lymphangiogenesis, tumor metabolism, growth, and …