JWH018, a common constituent of 'Spice' herbal blends, is a potent and efficacious cannabinoid CB1 receptor agonist
Background and purpose:'Spice'is an herbal blend primarily marketed in Europe as a mild
hallucinogen with prominent cannabis‐like effects and as a legal alternative to cannabis …
hallucinogen with prominent cannabis‐like effects and as a legal alternative to cannabis …
CP47, 497-C8 and JWH073, commonly found in 'Spice'herbal blends, are potent and efficacious CB1 cannabinoid receptor agonists
BK Atwood, D Lee, A Straiker, TS Widlanski… - European journal of …, 2011 - Elsevier
'Spice'is an herbal blend that has been reported to produce cannabis-like effects when
smoked and is marketed as an alternative to marijuana. Synthetic additives have been …
smoked and is marketed as an alternative to marijuana. Synthetic additives have been …
Cannabichromene is a cannabinoid CB2 receptor agonist
M Udoh, M Santiago, S Devenish… - British Journal of …, 2019 - Wiley Online Library
Background and Purpose Cannabichromene (CBC) is one of the most abundant
phytocannabinoids in Cannabis spp. It has modest antinociceptive and anti‐inflammatory …
phytocannabinoids in Cannabis spp. It has modest antinociceptive and anti‐inflammatory …
Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor
RB Laprairie, AM Bagher, MEM Kelly… - British journal of …, 2015 - Wiley Online Library
Background and Purpose Cannabidiol has been reported to act as an antagonist at
cannabinoid CB1 receptors. We hypothesized that cannabidiol would inhibit cannabinoid …
cannabinoid CB1 receptors. We hypothesized that cannabidiol would inhibit cannabinoid …
Cannabinoid CB1 and CB2 receptor mechanisms underlie cannabis reward and aversion in rats
Background and Purpose Endocannabinoids are critically involved in brain reward
functions, mediated by activation of CB1 receptors, reflecting their high density in the brain …
functions, mediated by activation of CB1 receptors, reflecting their high density in the brain …
Functional CB2 type cannabinoid receptors at CNS synapses
NH Morgan, IM Stanford, GL Woodhall - Neuropharmacology, 2009 - Elsevier
To date, it has been thought that cannabinoid receptors in CNS are primarily of the CB1R
subtype, with CB2R expressed only in glia and peripheral tissues. However, evidence for …
subtype, with CB2R expressed only in glia and peripheral tissues. However, evidence for …
Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb
Δ 9-tetrahydrocannabinol binds cannabinoid (CB 1 and CB 2) receptors, which are activated
by endogenous compounds (endocannabinoids) and are involved in a wide range of …
by endogenous compounds (endocannabinoids) and are involved in a wide range of …
Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro
A Thomas, GL Baillie, AM Phillips… - British journal of …, 2007 - Wiley Online Library
Background and purpose: A nonpsychoactive constituent of the cannabis plant, cannabidiol
has been demonstrated to have low affinity for both cannabinoid CB1 and CB2 receptors …
has been demonstrated to have low affinity for both cannabinoid CB1 and CB2 receptors …
The plant cannabinoid Δ9‐tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice
Background and purpose: The phytocannabinoid, Δ9‐tetrahydrocannabivarin (THCV), can
block cannabinoid CB1 receptors. This investigation explored its ability to activate CB2 …
block cannabinoid CB1 receptors. This investigation explored its ability to activate CB2 …
Stimulation of in vivo dopamine transmission and intravenous self-administration in rats and mice by JWH-018, a Spice cannabinoid
MA De Luca, Z Bimpisidis, M Melis, M Marti… - …, 2015 - Elsevier
Abstract The synthetic cannabinoid 1-pentyl-3-(1-naphthoyl)-indole (JWH-018) has been
detected in about 140 samples of a smokable herbal mixture termed “Spice”. JWH-018 is a …
detected in about 140 samples of a smokable herbal mixture termed “Spice”. JWH-018 is a …