Epidemiological, neuropathological, and functional neuroimaging evidence implicates
global and regional disruptions in brain metabolism and energetics in the pathogenesis of …

Brain cells normally respond adaptively to bioenergetic challenges resulting from ongoing
activity in neuronal circuits, and from environmental energetic stressors such as food …

To a great extent, cognitive health depends on cerebrovascular health and a deeper
understanding of the subtle interactions between cerebrovascular function and cognition is …

A large body of evidence indicates that sporadic Alzheimer's disease (AD) is a vascular
disorder with neurodegenerative consequences and needs to be treated and managed as …

Reduced brain glucose utilization in early stages of Alzheimer disease, as measured within
vivopositron emission tomography, reflects potentially reversible down-regulation of gene …

The etiology of neurodegenerative diseases remains enigmatic; however, evidence for
defects in energy metabolism, excitotoxicity, and for oxidative damage is increasingly …

Technological advances have led to greater use of both structural and functional brain
imaging to assist with the diagnosis of dementia for the increasing numbers of people with …

Lower brain glucose metabolism is present before the onset of clinically measurable
cognitive decline in two groups of people at risk of Alzheimer's disease---carriers of …

Neurodegenerative diseases, including Alzheimer, Parkinson, Huntington, and amyotrophic
lateral sclerosis, are a prominent class of neurological diseases currently without a cure …

The brain requires a continuous supply of energy in the form of ATP, most of which is
produced from glucose by oxidative phosphorylation in mitochondria, complemented by …