Somatosensory afferents are traditionally classified by soma size, myelination, and their
response specificity to external and internal stimuli. Here, we propose the functional …

Although pain and itch are distinct sensations, most noxious chemicals are not very specific
to one sensation over the other, and recent discoveries are revealing that Trp channels …

In Romeo and Juliet, Shakespeare argues that the names of things are not as important as
the thing itself and how we identify it. Hansson's Topical Review [4] asks whether central …

It has long been appreciated that the experience of pain is highly variable between
individuals. Pain results from activation of sensory receptors specialized to detect actual or …

We provide evidence supporting the idea that the relationship between tissue damage, or
the threat of tissue damage, and the response to such stimuli is variant and dependent on …

Clinical pain is a serious public health issue. Treatment of pain-related suffering requires
knowledge of how pain signals are initially interpreted and subsequently transmitted and …

Spinal cord injury (SCI) causes chronic peripheral sensitization of nociceptors and persistent
generation of spontaneous action potentials (SA) in peripheral branches and the somata of …

Pain is an essential physiological defense against danger, be it external, from the
environment, or internal, arising from within the body. The initiation of this acute defensive …

The ability to locate pain plays a pivotal role in immediate defense and withdrawal behavior.
However, how the brain localizes nociceptive information without additional information from …

The exteroceptive somatosensory system is important for reflexive and adaptive behaviors
and for the dynamic control of movement in response to external stimuli. This review outlines …