Chondroitin sulfate proteoglycans and heparan sulfate proteoglycans are major constituents
of the extracellular matrix and the cell surface in the brain. Proteoglycans bind with many …

Proteoglycans are a heterogeneous class of proteins bearing sulfated glycosaminoglycans.
Some of the proteoglycans have distinct core protein structures, and others display …

The extracellular matrix (ECM) in the central nervous system actively orchestrates and
modulates changes in neural structure and function in response to experience, after injury …

Extracellular matrix (ECM) molecules in the central nervous system form highly organized
ECM structures around cell somata, axon initial segments, and synapses and play …

Proteoglycans are ubiquitous cell-surface and secreted glycoproteins that are involved in
diverse cellular behaviors. The identities of several nervous system Proteoglycans, including …

Chondroitin sulfate proteoglycans (CSPGs) abnormally accumulate in cerebrospinal fluid
(CSF) of both human neonates with preterm hydrocephalus, and P8 hydrocephalic mice. We …

Proteoglycans are diverse, complex extracellular/cell surface macromolecules composed of
a central core protein with covalently linked glycosaminoglycan (GAG) chains; both of these …

Cellular interactions in neural development are influenced by various extracellular proteins,
many of which bind glycosaminoglycans or proteoglycans. Precise functions of nervous …

Large numbers of different proteoglycans are expressed in tightly regulated spatio-temporal
patterns by both the nerve cells (neurons) and the supporting glial cells of the nervous …

Chondroitin sulfate proteoglycans (CSPGs), including neurocan and phosphocan, are
believed to be major components of brain extracellular matrix that interact with other matrix …