Directing induced pluripotent stem cell derived neural stem cell fate with a three-dimensional biomimetic hydrogel for spinal cord injury repair

L Fan, C Liu, X Chen, Y Zou, Z Zhou, C Lin… - … applied materials & …, 2018 - ACS Publications
Current treatment approaches for spinal cord injuries (SCIs) are mainly based on cellular
transplantation. Induced pluripotent stem cells (iPSCs) without supply constraints and ethical …

Dual-enzymatically cross-linked gelatin hydrogel enhances neural differentiation of human umbilical cord mesenchymal stem cells and functional recovery in …

M Yao, J Li, J Zhang, S Ma, L Wang, F Gao… - Journal of Materials …, 2021 - pubs.rsc.org
Recently, an advanced stem cell and tissue engineering approach has been recognized as
an emerging and fascinating strategy to promote neural repair in spinal cord injury (SCI) …

Promoting 3D neuronal differentiation in hydrogel for spinal cord regeneration

P Zhou, P Xu, J Guan, C Zhang, J Chang… - Colloids and Surfaces B …, 2020 - Elsevier
Spinal cord injury (SCI) affects millions of people worldwide, and results in the loss of
neurons and limited recovery of functions. Bone mesenchymal stem cells (BMSCs) and …

NSC-derived extracellular matrix-modified GelMA hydrogel fibrous scaffolds for spinal cord injury repair

Z Chen, L Wang, C Chen, J Sun, J Luo, W Cui… - NPG Asia …, 2022 - nature.com
Cell-derived extracellular matrix (ECM) has been applied in spinal cord injury (SCI)
regeneration because of its various biological functions. However, insufficient mechanical …

Encapsulation of human spinal cord progenitor cells in hyaluronan-gelatin hydrogel for spinal cord injury treatment

C Kwokdinata, V Ramanujam, J Chen… - … Applied Materials & …, 2023 - ACS Publications
Transplanting human induced pluripotent stem cells (iPSCs)-derived spinal cord progenitor
cells (SCPCs) is a promising approach to treat spinal cord injuries. However, stem cell …

An electroconductive hydrogel scaffold with injectability and biodegradability to manipulate neural stem cells for enhancing spinal cord injury repair

H Liu, Y Feng, S Che, L Guan, X Yang, Y Zhao… - …, 2022 - ACS Publications
Spinal cord injury (SCI) generally leads to long-term functional deficits and is difficult to
repair spontaneously. Many biological scaffold materials and stem cell treatment strategies …

Regenerating the injured spinal cord at the chronic phase by engineered iPSCs‐derived 3D neuronal networks

L Wertheim, R Edri, Y Goldshmit, T Kagan… - Advanced …, 2022 - Wiley Online Library
Cell therapy using induced pluripotent stem cell‐derived neurons is considered a promising
approach to regenerate the injured spinal cord (SC). However, the scar formed at the …

Injectable nanoreinforced shape-memory hydrogel system for regenerating spinal cord tissue from traumatic injury

C Wang, H Yue, Q Feng, B Xu, L Bian… - ACS applied materials & …, 2018 - ACS Publications
Traumatic injury in the central nervous system can lead to loss of functional neurons.
Transplantation of neural progenitors is a promising therapeutic strategy. However, infusion …

[HTML][HTML] Cell-adaptable dynamic hydrogel reinforced with stem cells improves the functional repair of spinal cord injury by alleviating neuroinflammation

X Yuan, W Yuan, L Ding, M Shi, L Luo, Y Wan, J Oh… - Biomaterials, 2021 - Elsevier
Spinal cord injury (SCI) is one of the most challenging clinical issues. It is characterized by
the disruption of neural circuitry and connectivity, resulting in neurological disability. Adipose …

Coaxial 3D printing of hierarchical structured hydrogel scaffolds for on-demand repair of spinal cord injury

Y Li, S Cheng, H Wen, L Xiao, Z Deng, J Huang… - Acta Biomaterialia, 2023 - Elsevier
After spinal cord injury (SCI), endogenous neural stem cells (NSCs) near the damaged site
are activated, but few NSCs migrate to the injury epicenter and differentiate into neurons …