ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice
Genes encoding subunits of SWI/SNF (BAF) chromatin-remodeling complexes are
collectively mutated in∼ 20% of all human cancers,. Although ARID1A is the most frequent …
collectively mutated in∼ 20% of all human cancers,. Although ARID1A is the most frequent …
Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers
ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, is frequently mutated in
cancer. Deficiency in its homolog ARID1B is synthetically lethal with ARID1A mutation …
cancer. Deficiency in its homolog ARID1B is synthetically lethal with ARID1A mutation …
ARID1A loss in cancer: towards a mechanistic understanding
R Mathur - Pharmacology & therapeutics, 2018 - Elsevier
Genes encoding subunits of SWI/SNF chromatin remodeling complexes are collectively
mutated in 20% of all human cancers. ARID1A is the SWI/SNF subunit gene that is most …
mutated in 20% of all human cancers. ARID1A is the SWI/SNF subunit gene that is most …
ARID1A Mutations in Cancer: Another Epigenetic Tumor Suppressor?
JN Wu, CWM Roberts - Cancer discovery, 2013 - AACR
Although disordered chromatin organization has long been recognized as a feature of
cancer, the molecular underpinnings of chromatin structure, epigenetic regulation, and their …
cancer, the molecular underpinnings of chromatin structure, epigenetic regulation, and their …
ARID1B is a specific vulnerability in ARID1A-mutant cancers
Recent studies have revealed that ARID1A, encoding AT-rich interactive domain 1A (SWI-
like), is frequently mutated across a variety of human cancers and also has bona fide tumor …
like), is frequently mutated across a variety of human cancers and also has bona fide tumor …
Dual ARID1A/ARID1B loss leads to rapid carcinogenesis and disruptive redistribution of BAF complexes
SWI/SNF chromatin remodelers play critical roles in development and cancer. The causal
links between SWI/SNF complex disassembly and carcinogenesis are obscured by …
links between SWI/SNF complex disassembly and carcinogenesis are obscured by …
[HTML][HTML] Acute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for activation and repression of transcription
S Blümli, N Wiechens, MY Wu, V Singh, M Gierlinski… - Cell reports, 2021 - cell.com
The ARID1A subunit of SWI/SNF chromatin remodeling complexes is a potent tumor
suppressor. Here, a degron is applied to detect rapid loss of chromatin accessibility at …
suppressor. Here, a degron is applied to detect rapid loss of chromatin accessibility at …
ARID1A facilitates KRAS signaling-regulated enhancer activity in an AP1-dependent manner in colorectal cancer cells
Abstract Background ARID1A (AT-rich interactive domain-containing protein 1A) is a subunit
of the BAF chromatin remodeling complex and plays roles in transcriptional regulation and …
of the BAF chromatin remodeling complex and plays roles in transcriptional regulation and …
Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming
Somatic inactivating mutations of ARID1A, a SWI/SNF chromatin remodeling gene, are
prevalent in human endometrium-related malignancies. To elucidate the mechanisms …
prevalent in human endometrium-related malignancies. To elucidate the mechanisms …
Recurrent inactivating mutations of ARID2 in non‐small cell lung carcinoma
G Manceau, E Letouzé, C Guichard… - … journal of cancer, 2013 - Wiley Online Library
In eukaryotic cells, DNA is packaged into chromatin and this compact storage in the nucleus
promotes transcriptional repression of genes. Chromatin remodeling complexes such as the …
promotes transcriptional repression of genes. Chromatin remodeling complexes such as the …