International meta-analysis of PTSD genome-wide association studies identifies sex-and ancestry-specific genetic risk loci

CM Nievergelt, AX Maihofer, T Klengel… - Nature …, 2019 - nature.com
The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust
common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 …

[HTML][HTML] Enhancing discovery of genetic variants for posttraumatic stress disorder through integration of quantitative phenotypes and trauma exposure information

AX Maihofer, KW Choi, JRI Coleman, NP Daskalakis… - Biological …, 2022 - Elsevier
Background Posttraumatic stress disorder (PTSD) is heritable and a potential consequence
of exposure to traumatic stress. Evidence suggests that a quantitative approach to PTSD …

Genetics of post-traumatic stress disorder: review and recommendations for genome-wide association studies

MC Cornelis, NR Nugent, AB Amstadter… - Current psychiatry …, 2010 - Springer
Post-traumatic stress disorder (PTSD) is a prevalent, disabling anxiety disorder that
constitutes a major health care burden. Despite evidence supporting a genetic …

Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder

CM Nievergelt, AX Maihofer, EG Atkinson, CY Chen… - Nature Genetics, 2024 - nature.com
Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability
than most other psychiatric disorders. The contribution to biological understanding from …

Genomic approaches to posttraumatic stress disorder: the psychiatric genomic consortium initiative

CM Nievergelt, AE Ashley-Koch, S Dalvie… - Biological …, 2018 - Elsevier
Posttraumatic stress disorder (PTSD) after exposure to a traumatic event is a highly
prevalent psychiatric disorder. Heritability estimates from twin studies as well as from recent …

Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program

MB Stein, DF Levey, Z Cheng, FR Wendt… - Nature …, 2021 - nature.com
We conducted genome-wide association analyses of over 250,000 participants of European
(EUR) and African (AFR) ancestry from the Million Veteran Program using electronic health …

Genome-wide association study of posttraumatic stress disorder in a cohort of Iraq–Afghanistan era veterans

AE Ashley-Koch, ME Garrett, J Gibson, Y Liu… - Journal of affective …, 2015 - Elsevier
Background Posttraumatic stress disorder (PTSD) is a psychiatric disorder that can develop
after experiencing traumatic events. A genome-wide association study (GWAS) design was …

Genome-wide association studies of posttraumatic stress disorder in 2 cohorts of US Army soldiers

MB Stein, CY Chen, RJ Ursano, T Cai… - JAMA …, 2016 - jamanetwork.com
Importance Posttraumatic stress disorder (PTSD) is a prevalent, serious public health
concern, particularly in the military. The identification of genetic risk factors for PTSD may …

Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder

P Xie, HR Kranzler, C Yang, H Zhao, LA Farrer… - Biological …, 2013 - Elsevier
Background Genetic factors influence the risk for posttraumatic stress disorder (PTSD), a
potentially chronic and disabling psychiatric disorder that can arise after exposure to trauma …

The genetics and epigenetics of PTSD: overview, recent advances, and future directions

CM Sheerin, MJ Lind, KE Bountress, NR Nugent… - Current opinion in …, 2017 - Elsevier
Highlights•Over 100 candidate gene studies have been conducted to date.•Candidate gene
studies of the HPA-axis system appear to be promising.•Genome-wide association studies …