The data-independent acquisition (DIA) approach has recently been introduced as a novel
mass spectrometric method that promises to combine the high content aspect of shotgun …

To address the increasing need for detecting and validating protein biomarkers in clinical
specimens, mass spectrometry (MS)-based targeted proteomic techniques, including the …

We describe an improved version of the data‐independent acquisition (DIA) computational
analysis tool DIA‐Umpire, and show that it enables highly sensitive, untargeted, and direct …

Comprehensive, reproducible and precise analysis of large sample cohorts is one of the key
objectives of quantitative proteomics. Here, we present an implementation of data …

The performance of data-independent acquisition (DIA) mass spectrometry (MS) depends
on the separation efficiency of peptide precursors. In Orbitrap-based mass spectrometers …

Targeted quantitative proteomic analyses aim at systematically measuring the abundance of
proteins in large sets of samples, without biases or missing values. One typical …

Proteomics is gradually complementing large shotgun qualitative studies with hypothesis-
driven quantitative experiments. Targeted analyses performed on triple quadrupole …

Most proteomic studies use liquid chromatography coupled to tandem mass spectrometry to
identify and quantify the peptides generated by the proteolysis of a biological sample …

Targeted high-resolution and accurate mass analyses performed on fast sequencing mass
spectrometers have opened new avenues for quantitative proteomics. More specifically …

Introduction: While selected/multiple-reaction monitoring (SRM or MRM) is considered the
gold standard for quantitative protein measurement, emerging data-independent acquisition …