Reverse repurposing: Potential utility of cancer drugs in nonmalignant illnesses

M Nikanjam, K Wells, S Kato, JJ Adashek, S Block… - Med, 2024 - cell.com
Growth and immune process dysregulation can result in both cancer and nonmalignant
disease (hereditary or acquired, with and without predisposition to malignancy). Moreover …

[HTML][HTML] “Hard” drug repurposing for precision oncology: the missing link?

P Pantziarka, G Bouche, N André - Frontiers in Pharmacology, 2018 - frontiersin.org
Drug repurposing is at the heart of precision oncology. The move from tissue-or cancer-
specific treatments to genomic-or actionable-target treatments necessarily entails the reuse …

Turning liabilities into opportunities: Off-target based drug repurposing in cancer

V Palve, Y Liao, LLR Rix, U Rix - Seminars in cancer biology, 2021 - Elsevier
Targeted drugs and precision medicine have transformed the landscape of cancer therapy
and significantly improved patient outcomes in many cases. However, as therapies are …

Repurposing drugs in your medicine cabinet: untapped opportunities for cancer therapy?

P Pantziarka, G Bouche, L Meheus, V Sukhatme… - Future …, 2015 - Future Medicine
Many forms of cancer lack efficacious treatments, despite continuing advances in our
understanding of molecular biology, and the development of precisely targeted agents that …

Revitalizing Cancer Treatment: Exploring the Role of Drug Repurposing

RR Malla, S Viswanathan, S Makena, S Kapoor… - Cancers, 2024 - mdpi.com
Simple Summary Drug repurposing is emerging as a promising avenue for addressing
clinical challenges in treating drug-resistant and metastatic cancers. As a case study, some …

[HTML][HTML] Adopting drug repurposing to overcome drug resistance in cancer

E Shankar, V Subramaniam… - Frontiers in Cell and …, 2023 - frontiersin.org
Despite significant technological advances the etiology of cancer and mechanism disease
progression, and their translation into therapeutic benefits has been considerably slow …

Overcoming cancer therapeutic bottleneck by drug repurposing

Z Zhang, L Zhou, N Xie, EC Nice, T Zhang… - Signal transduction and …, 2020 - nature.com
Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …

Repurposing non-cancer Drugs in Oncology–How many drugs are out there?

P Pantziarka, V Sukhatme, L Meheus, V Sukhatme… - bioRxiv, 2017 - biorxiv.org
Background Drug repurposing can speed up access to new therapeutic options for cancer
patients. With more than 2000 drugs approved worldwide and 6 relevant targets per drug on …

[HTML][HTML] DRUG REPURPOSING—Overcoming the translational hurdles to clinical use

JH Martin, NA Bowden - Pharmacology Research & Perspectives, 2019 - ncbi.nlm.nih.gov
Drug repurposing is a methodology for identifying new uses for approved or investigational
drugs outside the scope of the original medical indication. In the field of cancer drug …

[HTML][HTML] Giving drugs a second chance: overcoming regulatory and financial hurdles in repurposing approved drugs as cancer therapeutics

JJ Hernandez, M Pryszlak, L Smith, C Yanchus… - Frontiers in …, 2017 - frontiersin.org
The repositioning or “repurposing” of existing therapies for alternative disease indications is
an attractive approach that can save significant investments of time and money during drug …