Reverse repurposing: Potential utility of cancer drugs in nonmalignant illnesses
M Nikanjam, K Wells, S Kato, JJ Adashek, S Block… - Med, 2024 - cell.com
Growth and immune process dysregulation can result in both cancer and nonmalignant
disease (hereditary or acquired, with and without predisposition to malignancy). Moreover …
disease (hereditary or acquired, with and without predisposition to malignancy). Moreover …
[HTML][HTML] “Hard” drug repurposing for precision oncology: the missing link?
P Pantziarka, G Bouche, N André - Frontiers in Pharmacology, 2018 - frontiersin.org
Drug repurposing is at the heart of precision oncology. The move from tissue-or cancer-
specific treatments to genomic-or actionable-target treatments necessarily entails the reuse …
specific treatments to genomic-or actionable-target treatments necessarily entails the reuse …
Turning liabilities into opportunities: Off-target based drug repurposing in cancer
Targeted drugs and precision medicine have transformed the landscape of cancer therapy
and significantly improved patient outcomes in many cases. However, as therapies are …
and significantly improved patient outcomes in many cases. However, as therapies are …
Repurposing drugs in your medicine cabinet: untapped opportunities for cancer therapy?
P Pantziarka, G Bouche, L Meheus, V Sukhatme… - Future …, 2015 - Future Medicine
Many forms of cancer lack efficacious treatments, despite continuing advances in our
understanding of molecular biology, and the development of precisely targeted agents that …
understanding of molecular biology, and the development of precisely targeted agents that …
Revitalizing Cancer Treatment: Exploring the Role of Drug Repurposing
RR Malla, S Viswanathan, S Makena, S Kapoor… - Cancers, 2024 - mdpi.com
Simple Summary Drug repurposing is emerging as a promising avenue for addressing
clinical challenges in treating drug-resistant and metastatic cancers. As a case study, some …
clinical challenges in treating drug-resistant and metastatic cancers. As a case study, some …
[HTML][HTML] Adopting drug repurposing to overcome drug resistance in cancer
E Shankar, V Subramaniam… - Frontiers in Cell and …, 2023 - frontiersin.org
Despite significant technological advances the etiology of cancer and mechanism disease
progression, and their translation into therapeutic benefits has been considerably slow …
progression, and their translation into therapeutic benefits has been considerably slow …
Overcoming cancer therapeutic bottleneck by drug repurposing
Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …
the development of the alternative strategy of drug repurposing, the development of old …
Repurposing non-cancer Drugs in Oncology–How many drugs are out there?
P Pantziarka, V Sukhatme, L Meheus, V Sukhatme… - bioRxiv, 2017 - biorxiv.org
Background Drug repurposing can speed up access to new therapeutic options for cancer
patients. With more than 2000 drugs approved worldwide and 6 relevant targets per drug on …
patients. With more than 2000 drugs approved worldwide and 6 relevant targets per drug on …
[HTML][HTML] DRUG REPURPOSING—Overcoming the translational hurdles to clinical use
Drug repurposing is a methodology for identifying new uses for approved or investigational
drugs outside the scope of the original medical indication. In the field of cancer drug …
drugs outside the scope of the original medical indication. In the field of cancer drug …
[HTML][HTML] Giving drugs a second chance: overcoming regulatory and financial hurdles in repurposing approved drugs as cancer therapeutics
JJ Hernandez, M Pryszlak, L Smith, C Yanchus… - Frontiers in …, 2017 - frontiersin.org
The repositioning or “repurposing” of existing therapies for alternative disease indications is
an attractive approach that can save significant investments of time and money during drug …
an attractive approach that can save significant investments of time and money during drug …