Bax, a central cell death regulator, is an indispensable gateway to mitochondrial dysfunction
and a major proapoptotic member of the B‐cell lymphoma 2 (Bcl‐2) family proteins that …

The BCL-2 family protein BAX is a major regulator of physiological and pathological cell
death. BAX predominantly resides in the cytosol in a quiescent state and upon stress, it …

Bax, a central death regulator, is required at the decisional stage of apoptosis. We recently
identified serine 184 (S184) of Bax as a critical functional switch controlling its proapoptotic …

The proapoptotic Bcl-2 protein Bax by itself is sufficient to initiate apoptosis in almost all
apoptotic paradigms. Thus, compounds that can facilitate disruptive Bax insertion into …

Bax is an essential mediator of mitochondria-dependent programed cell death. Bax belongs
to the Bcl-2 family of proteins and its activities are regulated through interaction with other …

Bcl-2-associated X protein (BAX) is a critical executioner of mitochondrial regulated cell
death through its lethal activity of permeabilizing the mitochondrial outer membrane (MOM) …

Pro-apoptotic BAX is a cell fate regulator playing an important role in cellular homeostasis
and pathological cell death. BAX is predominantly localized in the cytosol, where it has a …

Akt is a pro‐survival kinase frequently activated in human cancers and is associated with
more aggressive tumors that resist therapy. Here, we connect Akt pathway activation to …

BAX is a critical effector of the mitochondrial cell death pathway in response to a diverse
range of stimuli in physiological and disease contexts. Upon binding by BH3-only proteins …

BCL-2 family proteins are key regulators of the apoptotic pathway. Antiapoptotic members
sequester the BCL-2 homology 3 (BH3) death domains of proapoptotic members such as …