Abstract Mn (III) ortho-N-alkyl-and N-alkoxyalkyl porphyrins (MnPs) were initially developed
as superoxide dismutase (SOD) mimics. These compounds were later shown to react with …

Significance: After approximatelty three decades of research, two Mn (III) porphyrins (MnPs),
MnTE-2-PyP5+ (BMX-010, AEOL10113) and MnTnBuOE-2-PyP5+ (BMX-001), have …

Oxidative stress, a redox imbalance between the endogenous reactive species and
antioxidant systems, is common to numerous pathological conditions such as cancer, central …

Due to the ability to easily accept and donate electrons Mn (III) N-alkylpyridylporphyrins
(MnPs) can dismute O2·−, reduce peroxynitrite, but also generate reactive species and …

The most efficacious Mn (III) porphyrinic (MnPs) scavengers of reactive species have
positive charges close to the Mn site, whereby they afford thermodynamic and electrostatic …

Abstract Aims: Cationic manganese (Mn)-substituted N-pyridylporphyrin-based potent
mimics of the family of superoxide dismutases (SODs) protect normal tissues from injury …

Ascorbate (Asc) as a single agent suppressed growth of several tumor cell lines in a mouse
model. It has been tested in a Phase I Clinical Trial on pancreatic cancer patients where it …

Twenty-five years of development gave rise to several lead Mn porphyrins (MnPs) that
proved of remarkable efficacy in animal models and are developed towards Clinic. The one …

Superoxide dismutase/catalase mimetics, such as salen Mn complexes and certain
metalloporphyrins, catalytically neutralize reactive oxygen and nitrogen species, which have …

Superoxide dismutase (SOD) and catalase activities of a drug are of great importance for its
effective protection against reactive oxygen species (ROS)-induced injury. Achievement of …