The main goal of chemotherapeutic drugs is to induce massive cell death in tumors.
Cisplatin is an antitumor drug widely used to treat several types of cancer. Despite its …

Platinum-based chemotherapies, such as cisplatin, play a large role in cancer treatment.
The development of resistance and treatment toxicity creates substantial barriers to disease …

Simple Summary Cisplatin is successfully used for the treatment of various solid cancers.
Unfortunately, it shows no activity in colorectal cancer. The resistance phenotype of …

Platinum-based drugs, and in particular cis-diamminedichloroplatinum (II)(best known as
cisplatin), are employed for the treatment of a wide array of solid malignancies, including …

Although cisplatin has been a pivotal chemotherapy drug in treating patients with various
types of cancer for decades, drug resistance has been a major clinical impediment. In …

cis-Diamminedichloroplatinum (II)(cisplatin) is among the most active antitumour agent used
in human chemotherapy. The purpose of this review is to give an insight in several …

Cisplatin is one of the most potent antitumor agents known, displaying clinical activity
against a wide variety of solid tumors. Its cytotoxic mode of action is mediated by its …

cis-diamminedichloroplatinum (II) or cisplatin is a DNA-damaging agent that is widely used
in cancer chemotherapy. Cisplatin cross-links to DNA, forming intra-and interstrand adducts …

Cisplatin is one of the most effective anticancer agents widely used in the treatment of solid
tumors. It is generally considered as a cytotoxic drug which kills cancer cells by damaging …

Cisplatin and carboplatin are among the most active and widely used cytotoxic anticancer
drugs. However, the acquisition or presence of resistance significantly undermines the …