Summary HIV-1 envelope (Env) conformation determines the susceptibility of infected CD4+
T cells to antibody-dependent cellular cytotoxicity (ADCC). Upon interaction with CD4, Env …

ABSTRACT Anti-HIV-1 envelope glycoprotein (Env) antibodies without broadly neutralizing
activity correlated with protection in the RV144 clinical trial, stimulating interest in other …

ABSTRACT HIV-1-infected cells expressing envelope glycoproteins (Env) in the CD4-bound
conformation on their surfaces are targeted by antibody-dependent cellular cytotoxicity …

HIV-1-infected cells presenting envelope glycoproteins (Env) in the CD4-bound
conformation on their surface are preferentially targeted by antibody-dependent cell …

Recent studies have linked antibody Fc-mediated effector functions with control of human
immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus infections …

Human immunodeficiency virus type 1 (HIV-1) infection causes a progressive depletion of
CD4+ T cells. Despite its importance for HIV-1 pathogenesis, the precise mechanisms …

Background HIV proteins Nef and Vpu down-modulate various host factors to evade immune
defenses. Indeed, the CD4 receptor is down-regulated by Nef and Vpu, whereas virion …

Small CD4-mimetic compounds (CD4mc) sensitize HIV-1-infected cells to antibody-
dependent cellular cytotoxicity (ADCC) by facilitating antibody recognition of epitopes that …

ABSTRACT CD4 downregulation on infected cells is a highly conserved function of primate
lentiviruses. It has been shown to positively impact viral replication by a variety of …

ABSTRACT The HIV-1 Nef and Vpu accessory proteins are known to protect infected cells
from antibody-dependent cellular cytotoxicity (ADCC) responses by limiting exposure of …