The main objective of this study was to assess the effect of rich artificial cation adjusted
Mueller-Hinton broth (CAMHB), on the growth of three Acinetobacter baumannii strains …

The inoculum effect (ie, reduction in antimicrobial activity at large starting inoculum) is a
phenomenon described for various pathogens. Given that limited data exist regarding …

Objectives To expand on previous reports of synergy between polymyxin B (PMB) and
minocycline (MIN) against Acinetobacter baumannii; and to gain insight into the qualitative …

The reduction in antimicrobial activity at high bacterial counts is a microbiological
phenomenon known as the inoculum effect (IE). In a previous in vitro study, a significant IE …

In this study, the activity of meropenem (MEM), fosfomycin (FOF) and polymyxin B (PMB),
alone and in combination, was analysed. In addition, optimisation of the pharmacodynamic …

Purpose To study the in vitro and in vivo antibacterial activities of polymyxin B (PB) and other
five antimicrobial agents, including imipenem (IMP), meropenem (MEM), tigecycline (TGC) …

Administering polymyxin antibiotics in a traditional fashion may be ineffective against Gram-
negative ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae …

Despite limited data, polymyxin B (PB) is increasingly used clinically as the last therapeutic
option for multidrug-resistant (MDR) gram-negative bacterial infections. We examined the in …

Objectives Polymyxin B is being increasingly utilized as a last resort against resistant Gram-
negative bacteria. We examined the pharmacodynamics of novel dosing strategies for …

Objectives Antimicrobial resistance is a major global threat. Because of the stagnant
antibiotic pipeline, synergistic antibiotic combination therapy has been proposed to treat …