Chronic pancreatitis (CP) is a persistent inflammation of the pancreas. Over the past 12
years, genetic studies of hereditary, familial, and idiopathic forms of CP have made great …

Chronic pancreatitis (CP) is a clinical situation with persisting inflammation leading to
destruction of the pancreas ensuing endocrine and exocrine failure. There are 4 subtypes …

Chronic pancreatitis is a persistent inflammation of the pancreas that results in irreversible
morphological changes and impairment of both exocrine and endocrine functions. Genetic …

Acute pancreatitis and chronic pancreatitis are complex inflammatory disorders of the
pancreas with unpredictable severity, complications, and clinical courses. Growing evidence …

Objectives: Chronic pancreatitis is a progressive inflammatory disorder leading to
irreversible exocrine and/or endocrine impairment. It is well documented that mutations in …

Acute recurrent/chronic pancreatitis (CP) is a complex multigenic disease. This is a case–
control study consisting of 25 Greek patients with CP and a control population of 236 healthy …

Genetic investigations have provided unique insight into the mechanism of chronic
pancreatitis in humans and firmly established that uncontrolled trypsin activity is a central …

Chronic pancreatitis (CP) is characterized by progressive pancreatic damage that eventually
results in significant impairment of exocrine as well as endocrine functions of the gland. In …

Progress made in identifying the genetic susceptibility underlying acute and chronic
pancreatitis has benefitted the clinicians in understanding the pathogenesis of the disease …

The recent genetic discoveries in CP support the hypothesis that inappropriate
intrapancreatic activation of zymogens by trypsin results in autodigestion and pancreatitis …