Abstract Background and Objectives Doxepin, dosulepin, and clomipramine are tricyclic
antidepressants (TCAs) that act as serotonin and noradrenaline reuptake inhibitors. The …

The effect of cimetidine and ranitidine on doxepin pharmacokinetics was studied in 6 healthy
volunteers. Each subject completed 3 study phases: Treatment A, 9 consecutive doses of 50 …

The antidepressant activities of hispidol and decursin (both potent monoamine oxidase A
(MAO-A) inhibitors) were evaluated using the forced swimming test (FST) and the tail …

Selective deuterium substitution as a means of ameliorating clinically relevant
pharmacokinetic drug interactions is demonstrated in this study. Carbon-deuterium bonds …

JJH201501, a deuterated modification for multi-target antidepressant vortioxetine, is
currently in phase I clinical trial. This study aimed to establish a sensitive and rapid UPLC …

Many drugs are carbon-based, and carbon–hydrogen bonding is particularly relevant for
understanding important properties of drug molecules. Deuteration refers to the selective …

In organic chemistry, the use of deuterium exchange as a tool to study the mechanism of
chemical reaction has been well explored. Since two decades, the research focus on …

Introduction: Deuterated versions of existing drugs can exhibit improved pharmacokinetic or
toxicological properties due the stronger deuterium–carbon bond modifying their …

A deuterated drug comprises diminutive molecules in which deuterium replaces one or more
than one hydrogen atoms of the molecule. As deuterium and hydrogen possess almost …

Many drugs have adverse absorption, distribution, metabolism, and excretory (ADME)
properties that prevent their widespread use or limit their use in some indications. In addition …