STUDY QUESTION How does trophoblast plugging impact utero-placental
haemodynamics? SUMMARY ANSWER Physiological trophoblast plug structures are dense …

STUDY QUESTION What is the physiological extent of vascular remodelling in and
trophoblast plugging of the uterine circulation across the first half of pregnancy? SUMMARY …

STUDY QUESTION Does the use of a vascular contrast agent facilitate earlier detection of
maternal flow to the placental intervillous space (IVS) in the first trimester of pregnancy …

During the first trimester of pregnancy, foetal endovascular trophoblasts invade into maternal
spiral arteries, accumulate and form plugs in the lumen of the vessels. These plugs only …

Uterine spiral arteries play a vital role in supplying nutrients to the placenta and fetus, and
for this purpose they are remodelled into highly dilated vessels by the action of invading …

The ability of the baby to receive nutrients and oxygen in utero depends on the healthy
development of the placenta. For maternal blood to adequately perfuse the placenta, it …

It is now well known that in order to establish human hemochorial placentation and to
provide a progressive increase in blood supply to the growing fetus, the uterine spiral …

The purpose of this study was to establish the time course and hemodynamic significance of
de novo formed and enlarged uteroplacental arteries during pregnancy. Using x-ray …

The remodelling of the maternal uterine spiral arteries during pregnancy, known as
physiological change, is critical for the normal growth and development of the fetus …

Pre-eclampsia is associated with insufficient adaptations of spiral arteries which theoretically
alter haemodynamics within the intervillous space. Such changes could damage the …