Anti‐Inflammatory Properties of Low and High Doxycycline Doses: An In Vitro Study

R Di Caprio, S Lembo, L Di Costanzo… - Mediators of …, 2015 - Wiley Online Library
Doxycycline is used to treat infective diseases because of its broadspectrum efficacy. High
dose administration (100 or 200 mg/day) is often responsible for development of bacterial …

Doxycycline reduces lipopolysaccharide‐induced inflammatory mediator secretion in macrophage and ex vivo human whole blood models

J Cazalis, C Bodet, G Gagnon… - Journal of …, 2008 - Wiley Online Library
Background: Tetracyclines have been extensively used as adjuncts in the treatment of some
forms of periodontitis. The aim of this study was to evaluate the capacity of doxycycline to …

Effects of subantimicrobial-dose doxycycline in the treatment of moderate acne

R Skidmore, R Kovach, C Walker, J Thomas… - Archives of …, 2003 - jamanetwork.com
Objective To determine if treatment with subantimicrobial-dose (SD) doxycycline hyclate (20-
mg tablets taken twice daily) improved clinical outcome, had any detectable effect on skin …

Safety and efficacy review of doxycycline

NE Holmes, PGP Charles - Clinical Medicine. Therapeutics, 2009 - journals.sagepub.com
Doxycycline is a member of the tetracycline class of antibiotics and has been used clinically
for more than 40 years. It is a well-tolerated drug that is bacteriostatic and acts via the …

Doxycycline as an anti‐inflammatory agent: updates in dermatology

M Henehan, M Montuno… - Journal of the European …, 2017 - Wiley Online Library
Doxycycline, a tetracycline antibiotic, is widely used in the field of dermatology for its
antibiotic properties, anti‐inflammatory properties and good safety profile. Over the past …

Protection against endotoxic shock and lipopolysaccharide-induced local inflammation by tetracycline: correlation with inhibition of cytokine secretion

L Shapira, WA Soskolne, Y Houri, V Barak… - Infection and …, 1996 - Am Soc Microbiol
Septic shock results from excessive stimulation of host immune cells, particularly monocytes
and macrophages, by lipopolysaccharide (LPS) released from gram-negative bacteria …

[PDF][PDF] A status report on the use of subantimicrobial-dose doxycycline: a review of the biologic and antimicrobial effects of the tetracyclines

JQ Del Rosso - Cutis, 2004 - cdn.mdedge.com
Drug Therapy Topics have demonstrated efficacy with lower doses. 1, 3 A common finding
noted by clinicians is that oral antibiotics at lower doses have often maintained control of …

Subantimicrobial-dose doxycycline in the treatment of moderate facial acne.

P Toossi, M Farshchian, F Malekzad… - Journal of drugs in …, 2008 - europepmc.org
Background Acne is a common inflammatory skin disorder. Oral antibiotics play a significant
clinical role in treating acne. Objective The purpose of this study was to compare the efficacy …

Efficacy and safety of subantimicrobial dose, modified-release doxycycline 40 mg versus doxycycline 100 mg versus placebo for the treatment of inflammatory lesions …

A Moore, M Ling, A Bucko, V Manna… - Journal of drugs in …, 2015 - europepmc.org
Methods 662 subjects aged 12 years or older with moderate to severe acne received
subantimicrobial, MR-DC 40 mg tablets, DC 100 mg capsules, or placebo once daily for 16 …

Effects of low-dose doxycycline on cytokine secretion in human monocytes stimulated with Aggregatibacter actinomycetemcomitans

N Bostanci, B Akgül, V Tsakanika, RP Allaker… - Cytokine, 2011 - Elsevier
Doxycycline is an antibiotic used in the treatment of a variety of inflammatory conditions,
including periodontitis. Apart from its antimicrobial properties, this drug also has …