It is widely accepted that microglia-mediated inflammation contributes to the progression of
neurodegenerative diseases; however, the precise mechanisms through which these cells …

Cognitive impairments such as dementia are common in later life, and have been suggested
to occur via a range of mechanisms, including oxidative stress, age-related changes to …

Background and objectives Porcine liver decomposition product (PLDP) contains
neurofunctional phospholipids. We previously reported that PLDP enhances cognitive …

Neurodegenerative diseases (NDs) commonly present misfolded and aggregated proteins.
Considerable research has been performed to unearth the molecular processes …

The study of microglia, the immune cells of the brain, has experienced a renaissance after
the discovery of microglia polarization. In fact, the concept that activated microglia can shift …

Neuroinflammation characterized by activation of glial cells is observed in various
neurodegenerative diseases including Alzheimer's disease (AD). Although the reduction of …

Microglia activation has emerged as a potential key factor in the pathogenesis of Alzheimer's
disease. Metabolite levels assessed by magnetic resonance spectroscopy (MRS) are used …

Alzheimer's disease (AD) is an aging-dependent, irreversible neurodegenerative disorder
and the most common cause of dementia. The prevailing AD hypothesis points to the central …

Background Age-related cognitive decline (ARCD) is of major societal concern in an ageing
population, with the development of dietary supplements providing a promising avenue for …

Significance: Under physiological conditions, neurons and glia are in a healthy, redox-
balanced environment; when injury perturbs this equilibrium, a neuroinflammatory state is …