Membrane lipid raft organization is uniquely modified by n-3 polyunsaturated fatty acids

HF Turk, RS Chapkin - Prostaglandins, Leukotrienes and Essential Fatty …, 2013 - Elsevier
Fish oil, enriched in bioactive n-3 polyunsaturated fatty acids (PUFA), has been shown to
play a role in prevention of colon cancer. The effects of n-3 PUFA are pleiotropic and …

Mechanisms by which docosahexaenoic acid and related fatty acids reduce colon cancer risk and inflammatory disorders of the intestine

RS Chapkin, J Seo, DN McMurray, JR Lupton - Chemistry and physics of …, 2008 - Elsevier
A growing body of epidemiological, clinical, and experimental evidence has underscored
both the pharmacological potential and the nutritional value of dietary fish oil enriched in …

n− 3 Polyunsaturated fatty acids exert immunomodulatory effects on lymphocytes by targeting plasma membrane molecular organization

SR Shaikh, CA Jolly, RS Chapkin - Molecular aspects of medicine, 2012 - Elsevier
Fish oil, enriched in bioactive n− 3 polyunsaturated fatty acids (PUFA), has therapeutic value
for the treatment of inflammation-associated disorders. The effects of n− 3 PUFAs are …

[HTML][HTML] n-3 polyunsaturated fatty acids and their role in cancer chemoprevention

Z Gu, K Shan, H Chen, YQ Chen - Current pharmacology reports, 2015 - Springer
Polyunsaturated fatty acids (PUFAs), including omega-3 (n-3) and omega-6 (n-6) PUFAs,
are essential for human health. Recent research shows n-3 PUFAs and their mediators can …

Biophysical and biochemical mechanisms by which dietary N-3 polyunsaturated fatty acids from fish oil disrupt membrane lipid rafts

SR Shaikh - The Journal of nutritional biochemistry, 2012 - Elsevier
N-3 polyunsaturated fatty acids (PUFAs) from fish oil exert their functional effects by targeting
multiple mechanisms. One mechanism to emerge in the past decade is the ability of n-3 …

[HTML][HTML] Docosahexaenoic and eicosapentaenoic acids segregate differently between raft and nonraft domains

JA Williams, SE Batten, M Harris, BD Rockett… - Biophysical journal, 2012 - cell.com
Omega-3 polyunsaturated fatty acids (n-3 PUFA), enriched in fish oils, are increasingly
recognized to have potential benefits for treating many human afflictions. Despite the …

[HTML][HTML] Omega-3 polyunsaturated Fatty acids as potential chemopreventive agent for gastrointestinal cancer

JM Park, SH Kwon, YM Han, KB Hahm… - Journal of cancer …, 2013 - ncbi.nlm.nih.gov
Omega-3 polyunsaturated fatty acids (n-3 PUFAs), particularly eicosapentanoic acid (EPA)
and docosahexanoic acid (DHA), has been acknowledged as essential very long-chain fatty …

[HTML][HTML] Docosahexaenoic acid alters the size and distribution of cell surface microdomains

RS Chapkin, N Wang, YY Fan, JR Lupton… - Biochimica et Biophysica …, 2008 - Elsevier
We recently generated nutritional data suggesting that chemoprotective dietary n-3
polyunsaturated fatty acids (n-3 PUFA) are capable of displacing acylated proteins from lipid …

Closely related colon cancer cell lines display different sensitivity to polyunsaturated fatty acids, accumulate different lipid classes and downregulate sterol regulatory …

SA Schønberg, AG Lundemo, T Fladvad… - The FEBS …, 2006 - Wiley Online Library
N‐6 polyunsaturated fatty acids (PUFAs) may be associated with increased risk of colon
cancer, whereas n‐3 PUFAs may have a protective effect. We examined the effects of …

n-6 and n-3 polyunsaturated fatty acids differentially modulate oncogenic Ras activation in colonocytes

ED Collett, LA Davidson, YY Fan… - … of Physiology-Cell …, 2001 - journals.physiology.org
Ras proteins are critical regulators of cell function, including growth, differentiation, and
apoptosis, with membrane localization of the protein being a prerequisite for malignant …