Pannexin-1 (Panx1) hemichannel is a non-selective transmembrane channel that may play
important roles in intercellular signaling by allowing the permeation of ions and metabolites …

The threshold for bidirectional modification of synaptic plasticity is known to be controlled by
several factors, including the balance between protein phosphorylation and …

Enhanced activity and overexpression of Pannexin 1 (Panx1) channels contribute to
neuronal pathologies such as epilepsy and Alzheimer's disease (AD). The Panx1 channel …

Pannexin 1 (Panx1) represents a class of vertebrate membrane channels, bearing
significant sequence homology with the invertebrate gap junction proteins, the innexins and …

Long-term potentiation (LTP) and long-term depression (LTD) are two forms of synaptic
plasticity that have been considered as the cellular substrate of memory formation. Although …

Synaptic loss induced by soluble oligomeric forms of the amyloid β peptide (sAβos) is one of
the earliest events in Alzheimer's disease (AD) and is thought to be the major cause of the …

Astroglial release of molecules is thought to actively modulate neuronal activity, but the
nature, release pathway, and cellular targets of these neuroactive molecules are still …

Pannexin 1 (Panx1) channels are transmembrane proteins that release adenosine
triphosphate and play an important role in intercellular communication. They are widely …

Pannexin1 (Panx1) channels release cytosolic ATP in response to signaling pathways.
Panx1 is highly expressed in the central nervous system. We used four antibodies with …

Beta-amyloid protein [Aβ (1-42)] plays an important role in the disease progress and
pathophysiology of Alzheimer's disease (AD). Membrane properties and neuronal …