The understanding that zidovudine (ZDV or azidothymidine, AZT) inhibits the RNA-
dependent RNA polymerase (RdRp) of SARS-CoV-2 and that chalcogen atoms can …

In this investigation, we have optimized uridine and its acylated derivatives employing
density functional theory (DFT). All designed derivatives were optimized at the B3LYP/3-21G …

Abstract Background/Aim SARS‐CoV‐2 is one of the coronavirus families that emerged at
the end of 2019. It infected the respiratory system and caused a pandemic worldwide …

The RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 is one of the optimum targets
for antiviral drug design and development. The hydroxyl groups of cytidine structures were …

SMAK planned the experiments and supervised; MAH performed computational
experiments; AA, MI, and JF conducted the synthetic work; SMAK and MAH interpreted the …

Coronavirus induced disease-19 caused by SARS-CoV-2 has presented an unprecedented
health and economic crisis worldwide. Substantial progress has been made in the last two …

3-chymotrypsin-like protease (3CLPRO) is found in severe acute respiratory syndrome
coronavirus (SARS CoV)-2, and transmembrane protease serine 2 (TMPRSS-2) in humans …

Thymidine and thymidine-mimicking derivatives were found promising against
microorganisms which may inhibit the growth of microorganisms providing effective …

Covid-19 disease caused by the deadly SARS-CoV-2 virus is a serious and threatening
global health issue declared by the WHO as an epidemic. Researchers are studying the …

The infection produced by the SARS-CoV-2 virus remains a significant health crisis
worldwide. The lack of specific medications for COVID-19 necessitates a concerted effort to …