Hepatoprotective effect of baicalein against acetaminophen-induced acute liver injury in mice

HC Zhou, H Wang, K Shi, JM Li, Y Zong, R Du - Molecules, 2018 - mdpi.com
Baicalein (BAI), one of the main components of Scutellaria baicalensis Georgi, possesses
numerous pharmacological properties, including anti-cancer, anti-oxidative, anti-virus and …

ERK signaling pathway plays a key role in baicalin protection against acetaminophen-induced liver injury

CC Liao, YJ Day, HC Lee, JT Liou… - The American journal …, 2017 - World Scientific
Acetaminophen (APAP) overdose causes hepatocytes necrosis and acute liver failure.
Baicalin (BA), a major flavonoid of Scutellariae radix, has potent hepatoprotective properties …

Baicalin promotes liver regeneration after acetaminophen-induced liver injury by inducing NLRP3 inflammasome activation

L Shi, S Zhang, Z Huang, F Hu, T Zhang, M Wei… - Free Radical Biology …, 2020 - Elsevier
Liver regeneration has become a new hotspot in the study of drug-induced liver injury (DILI).
Baicalin has already been reported to alleviate acetaminophen (APAP)-induced acute liver …

Paeoniflorin protects against acetaminophen-induced liver injury in mice via JNK signaling pathway

X Deng, Y Li, X Li, Z Zhang, S Dai, H Wu, F Zhang… - Molecules, 2022 - mdpi.com
Background: Drug-induced liver injury (DILI), represented by acetaminophen (APAP), is a
common cause of acute liver failure in clinics. Paeoniflorin (PF) has been proven to …

Baicalein pretreatment protects against liver ischemia/reperfusion injury via inhibition of NF-κB pathway in mice

A Liu, L Huang, H Fan, H Fang, Y Yang, S Liu… - International …, 2015 - Elsevier
Abstract Ischemia/reperfusion (I/R) is a pathophysiologic process that occurs during
hemorrhagic shock, liver resection and liver transplantation. Baicalein, the main active …

Baicalein and baicalin alleviate acetaminophen-induced liver injury by activating Nrf2 antioxidative pathway: The involvement of ERK1/2 and PKC

L Shi, Z Hao, S Zhang, M Wei, B Lu, Z Wang… - Biochemical …, 2018 - Elsevier
Acetaminophen (APAP)-induced hepatotoxicity is the main cause of drug-induced liver
injury. This study investigated the protection of baicalin and its aglycone baicalein against …

[HTML][HTML] Shikonin attenuates acetaminophen-induced acute liver injury via inhibition of oxidative stress and inflammation

H Guo, J Sun, D Li, Y Hu, X Yu, H Hua, X Jing… - Biomedicine & …, 2019 - Elsevier
Acetaminophen (APAP) overdose causes acute liver injury and leads to fatal liver damage.
However, the therapies are quite limited. Shikonin is a natural product with antioxidant and …

[HTML][HTML] Cardamonin reduces acetaminophen-induced acute liver injury in mice via activating autophagy and NFE2L2 signaling

Q Xu, Y Fan, JJ Loor, Y Liang, X Sun, H Jia… - Frontiers in …, 2020 - frontiersin.org
Cardamonin (CD), a naturally occurring chalcone derived from the Alpinia species, has
been shown to exert antioxidant and anti-inflammatory activity, but its role in the prevention …

[HTML][HTML] Corilagin reduces acetaminophen-induced hepatotoxicity through MAPK and NF-κB signaling pathway in a mouse model

FC Liu, HP Yu, AH Chou, HC Lee… - American Journal of …, 2020 - ncbi.nlm.nih.gov
Corilagin is a major active polyphenolic tannins extracted from Phyllanthus urinaria, an
important herb used in traditional medicine. Previous reports demonstrated that corilagin …

Protective effect of baicalin against arsenic trioxide-induced acute hepatic injury in mice through JAK2/STAT3 signaling pathway

Q He, X Sun, M Zhang, L Chu, Y Zhao… - International …, 2022 - journals.sagepub.com
Baicalin (BA) is a kind of flavonoid that is isolated from Scutellaria baicalensis Georgi, which
has been verified to have hepatoprotective effects in some diseases. However, the role of …