Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease
Ageing is a major risk factor for many neurological pathologies, but its mechanisms remain
unclear. Unlike other tissues, the parenchyma of the central nervous system (CNS) lacks …
unclear. Unlike other tissues, the parenchyma of the central nervous system (CNS) lacks …
Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid
Recent work has shown that meningeal lymphatic vessels (mLVs), mainly in the dorsal part
of the skull, are involved in the clearance of cerebrospinal fluid (CSF), but the precise route …
of the skull, are involved in the clearance of cerebrospinal fluid (CSF), but the precise route …
Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy
Alzheimer's disease (AD) is the most prevalent cause of dementia. Although there is no
effective treatment for AD, passive immunotherapy with monoclonal antibodies against …
effective treatment for AD, passive immunotherapy with monoclonal antibodies against …
[HTML][HTML] Nasopharyngeal lymphatic plexus is a hub for cerebrospinal fluid drainage
Cerebrospinal fluid (CSF) in the subarachnoid space around the brain has long been known
to drain through the lymphatics to cervical lymph nodes,,,,,,,,,,,,,,,–, but the connections and …
to drain through the lymphatics to cervical lymph nodes,,,,,,,,,,,,,,,–, but the connections and …
Impaired meningeal lymphatic drainage in patients with idiopathic Parkinson's disease
XB Ding, XX Wang, DH Xia, H Liu, HY Tian, Y Fu… - Nature medicine, 2021 - nature.com
Animal studies implicate meningeal lymphatic dysfunction in the pathogenesis of
neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease (PD) …
neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease (PD) …
Drainage of senescent astrocytes from brain via meningeal lymphatic routes
Q Li, Y Chen, W Feng, J Cai, J Gao, F Ge… - Brain, Behavior, and …, 2022 - Elsevier
Recent progress on the central lymphatic system has greatly increased our understanding of
how the brain maintains its own waste homeostasis. Here, we showed that perivascular …
how the brain maintains its own waste homeostasis. Here, we showed that perivascular …
Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer's disease-associated pathology and cognition in mice
M Wang, C Yan, X Li, T Yang, S Wu, Q Liu… - Nature …, 2024 - nature.com
Meningeal lymphatic vessels (mLVs) have been shown to be involved in amyloid beta (Aβ)
clearance, which is considered as a potential therapeutic target for Alzheimer's disease …
clearance, which is considered as a potential therapeutic target for Alzheimer's disease …
Structural and functional features of central nervous system lymphatic vessels
One of the characteristics of the central nervous system is the lack of a classical lymphatic
drainage system. Although it is now accepted that the central nervous system undergoes …
drainage system. Although it is now accepted that the central nervous system undergoes …
Multisensory gamma stimulation promotes glymphatic clearance of amyloid
The glymphatic movement of fluid through the brain removes metabolic waste,,–.
Noninvasive 40 Hz stimulation promotes 40 Hz neural activity in multiple brain regions and …
Noninvasive 40 Hz stimulation promotes 40 Hz neural activity in multiple brain regions and …
Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice
Q Ma, BV Ineichen, M Detmar, ST Proulx - Nature communications, 2017 - nature.com
Cerebrospinal fluid (CSF) has been commonly accepted to drain through arachnoid
projections from the subarachnoid space to the dural venous sinuses. However, a lymphatic …
projections from the subarachnoid space to the dural venous sinuses. However, a lymphatic …