Osteoarthritis is a prevalent and debilitating disease that involves pathological contributions
from numerous joint tissues and cells. The joint is a challenging arena for drug delivery …

Understanding intra-articular biodistribution is imperative as candidate osteoarthritis (OA)
drugs become increasingly site-specific. Cartilage has been identified as opportunistic for …

Osteoarthritis is the most prevalent chronic and debilitating joint disease, resulting in huge
medical and socioeconomic burdens. Intra-articular administration of agents is clinically …

Osteoarthritis (OA) and rheumatoid arthritis (RA) are chronic and progressive inflammatory
joint diseases that affect a large population worldwide. Intra-articular administration of …

The management of osteoarthritis (OA) is a clinical challenge due to the particular avascular,
dense, and occluded tissue structure. Despite numerous clinical reports and animal studies …

Joint diseases are one of the most common causes of morbidity and disability worldwide.
The main diseases that affect joint cartilage are osteoarthritis and rheumatoid arthritis, which …

Highlights•We categorize the challenges and corresponding solutions for nano-drug
delivery in OA.•We summarize the design and advantages of recent nano-drug delivery …

A major hurdle limiting the ability to treat and cure osteoarthritis, a common and debilitating
disease, is rapid joint clearance and limited cartilage targeting of intra-articular therapies …

Osteoarthritis (OA） is a common orthopaedic disease in middle-aged and aged people. To
date, no disease-modifying drug is available to prevent the progression of OA. Surgical …

Rheumatoid arthritis is a systemic inflammatory disease that can lead to articular cartilage
destruction and periarticular bone erosion, thus ultimately compromising joint integrity and …