[HTML][HTML] Fuxin Granules ameliorate diabetic nephropathy in db/db mice through TGF-β1/Smad and VEGF/VEGFR2 signaling pathways

W Zheng, C Qian, F Xu, P Cheng, C Yang, X Li… - Biomedicine & …, 2021 - Elsevier
Diabetic nephropathy (DN) is a common disease, and patients often do not have satisfactory
treatments. We investigated therapeutic effects of Fuxin Granules (FX) on DN and potential …

[HTML][HTML] Low molecular weight fucoidan ameliorates diabetic nephropathy via inhibiting epithelial-mesenchymal transition and fibrotic processes

J Chen, W Cui, Q Zhang, Y Jia, Y Sun… - American journal of …, 2015 - ncbi.nlm.nih.gov
Diabetic nephropathy (DN) is one of the most serious microvascular complications of
diabetes and may lead to end-stage renal disease (ESRD) and chronic renal failure. The …

Low molecular weight fucoidan ameliorates the inflammation and glomerular filtration function of diabetic nephropathy

Y Xu, Q Zhang, D Luo, J Wang, D Duan - Journal of Applied Phycology, 2017 - Springer
Diabetic nephropathy (DN) is a type of serious microangiopathy that is caused by diabetes
mellitus (DM). It is the most common cause of chronic renal failure and end-stage renal …

[HTML][HTML] Fucoidan exerts protective effects against diabetic nephropathy related to spontaneous diabetes through the NF-κB signaling pathway in vivo and in vitro

Y Wang, M Nie, Y Lu, R Wang, J Li… - International …, 2015 - spandidos-publications.com
Fucoidan, an extract of the seaweed, Fucus vesiculosus, has been widely investigated for its
antioxidant effects. However, to date and to the best of our knowledge, pathological studies …

[HTML][HTML] FGF23C-tail improves diabetic nephropathy by attenuating renal fibrosis and inflammation

X Zhang, K Guo, F Xia, X Zhao, Z Huang, J Niu - BMC biotechnology, 2018 - Springer
Background High level of serum fibroblast growth factor 23 (FGF23) is implicated in the
development and progression of diabetic nephropathy (DN), making it a crucial factor in the …

[HTML][HTML] Oligo-fucoidan improves diabetes-induced renal fibrosis via activation of Sirt-1, GLP-1R, and Nrf2/HO-1: an in vitro and in vivo study

WC Yu, RY Huang, TC Chou - Nutrients, 2020 - mdpi.com
Fucoidan extracted from brown algae has multiple beneficial functions. In this study, we
investigated the effects of low-molecular-weight fucoidan (oligo-FO) on renal fibrosis under …

Inhibition of core fucosylation limits progression of diabetic kidney disease

M Fang, L Kang, X Wang, X Guo, W Wang, B Qin… - Biochemical and …, 2019 - Elsevier
Background FUT8-mediated core fucosylation, which transfers a fucose residue from GDP-
fucose to core-GlcNAc of the N-linked type glycoproteins, is crucial for signaling receptors …

Low molecular weight fucoidan can inhibit the fibrosis of diabetic kidneys by regulating the kidney lipid metabolism

Y Wang, Y Sun, F Shao, B Zhang… - Journal of Diabetes …, 2021 - Wiley Online Library
In this study, a diabetic kidney disease model was established by placing the test rats on a
high‐sugar/high‐fat diet combined with streptozotocin induction. Histopathological …

Attenuating effect of Fufang Xueshuantong Capsule on kidney function in diabetic nephropathy model

Q Zhang, X Xiao, M Li, W Li, M Yu, H Zhang… - Journal of natural …, 2013 - Springer
Abstract Fufang Xueshuantong Capsule (FXST) can reduce urinary albumin and whole
blood viscosity in early diabetic nephropathy (DN) patients. This research aimed to …

Fucoidan mitigated diabetic nephropathy through the downregulation of PKC and modulation of NF‐κB signaling pathway: in vitro and in vivo investigations

J Xu, Y Wang, Z Wang, L Guo, X Li - Phytotherapy Research, 2021 - Wiley Online Library
The persistence of hyperglycemia and oxidative stress in diabetic patients ultimately leads to
diabetic nephropathy (DN). In this study, we investigated the effect of sulfated …