Generational distribution of a Candida glabrata population: Resilient old cells prevail, while younger cells dominate in the vulnerable host

T Bouklas, L Alonso-Crisóstomo, T Székely Jr… - PLoS …, 2017 - journals.plos.org
Similar to other yeasts, the human pathogen Candida glabrata ages when it undergoes
asymmetric, finite cell divisions, which determines its replicative lifespan. We sought to …

One Small Step for a Yeast - Microevolution within Macrophages Renders Candida glabrata Hypervirulent Due to a Single Point Mutation

S Brunke, K Seider, D Fischer, ID Jacobsen… - PLoS …, 2014 - journals.plos.org
Candida glabrata is one of the most common causes of candidemia, a life-threatening,
systemic fungal infection, and is surpassed in frequency only by Candida albicans. Major …

Replicative aging remodels the cell wall and is associated with increased intracellular trafficking in human pathogenic yeasts

VKA Silva, S Bhattacharya, NK Oliveira, AG Savitt… - MBio, 2022 - Am Soc Microbiol
Replicative aging is an underexplored field of research in medical mycology. Cryptococcus
neoformans (Cn) and Candida glabrata (Cg) are dreaded fungal pathogens that cause fatal …

Ploidy variation and spontaneous haploid-diploid switching of Candida glabrata clinical isolates

Q Zheng, J Liu, J Qin, B Wang, J Bing, H Du, M Li, F Yu… - Msphere, 2022 - Am Soc Microbiol
The human fungal pathogen Candida glabrata is phylogenetically closely related to
Saccharomyces cerevisiae, a model eukaryotic organism. Unlike S. cerevisiae, which has …

Replicative aging in pathogenic fungi

S Bhattacharya, T Bouklas, BC Fries - Journal of Fungi, 2020 - mdpi.com
Candida albicans, Candida auris, Candida glabrata, and Cryptococcus neoformans are
pathogenic yeasts which can cause systemic infections in immune-compromised as well as …

The birth of a deadly yeast: tracing the evolutionary emergence of virulence traits in Candida glabrata

T Gabaldón, L Carreté - FEMS yeast research, 2016 - academic.oup.com
The yeast Candida glabrata is an opportunistic human fungal pathogen whose incidence
has increased in the last two decades. Despite its name, this yeast is only distantly related to …

[PDF][PDF] Intracellular survival of Candida glabrata in macrophages: immune evasion and persistence

L Kasper, K Seider, B Hube - FEMS Yeast Research, 2015 - academic.oup.com
Candida glabrata is a successful human opportunistic pathogen which causes superficial
but also life-threatening systemic infections. During infection, C. glabrata has to cope with …

Patterns of genomic variation in the opportunistic pathogen Candida glabrata suggest the existence of mating and a secondary association with humans

L Carreté, E Ksiezopolska, C Pegueroles… - Current Biology, 2018 - cell.com
Candida glabrata is an opportunistic fungal pathogen that ranks as the second most
common cause of systemic candidiasis. Despite its genus name, this yeast is more closely …

Immune evasion, stress resistance, and efficient nutrient acquisition are crucial for intracellular survival of Candida glabrata within macrophages

K Seider, F Gerwien, L Kasper, S Allert, S Brunke… - Eukaryotic …, 2014 - Am Soc Microbiol
Candida glabrata is both a human fungal commensal and an opportunistic pathogen which
can withstand activities of the immune system. For example, C. glabrata can survive …

From Saccharomyces cerevisiae to Candida glabrata in a few easy steps: important adaptations for an opportunistic pathogen

A Roetzer, T Gabaldón, C Schüller - FEMS microbiology letters, 2011 - academic.oup.com
The opportunistic human fungal pathogen Candida glabrata is closely related to
Saccharomyces cerevisiae, yet it has evolved to survive within mammalian hosts. Which …