Immune checkpoint blockade (ICB) has improved outcomes in some cancers. A major
limitation of ICB is that most patients fail to respond, which is partly attributable to …

The recent successes of immunotherapy have shifted the paradigm in cancer treatment, but
because only a percentage of patients are responsive to immunotherapy, it is imperative to …

Bariatric surgery is a sustainable weight loss approach, including vertical sleeve
gastrectomy (VSG). Obesity exacerbates tumor growth, while diet-induced weight loss …

Immunotherapy has recently emerged as a promising treatment option for many patients,
revolutionizing the established therapeutic approach against cancer. Immune checkpoints …

Cancer immunotherapy has been heralded as a breakthrough cancer treatment
demonstrating tremendous success in improving tumor responses and survival of patients …

ABSTRACT Programmed death-ligand 1 (PD-L1) and its receptor programmed cell death
protein 1 (PD-1) modulate antitumor immunity and are major targets of checkpoint blockade …

Cancer is one of the leading causes of morbidity and mortality worldwide. Traditional
treatments include surgery, chemotherapy and radiation therapy, and more recently targeted …

Obesity is a risk factor for cancer, but it may also be associated with improved treatment
outcomes in patients with cancer. 1 This notable phenomenon is called the obesity paradox …

Immune checkpoint therapy in breast cancer remains restricted to triple negative patients,
and long-term clinical benefit is rare. The primary aim of immune checkpoint blockade is to …

Aberrant energy status contributes to multiple metabolic diseases, including obesity,
diabetes, and cancer, but the underlying mechanism remains elusive. Here, we report that …