Communication within the glial cell ecosystem is essential for neuronal and brain health,–.
The influence of glial cells on the accumulation and clearance of β-amyloid (Aβ) and …

Microglia, the brain's resident macrophages, help to regulate brain function by removing
dying neurons, pruning non-functional synapses, and producing ligands that support …

The pathology of Alzheimer's disease has an inflammatory component that is characterized
by upregulation of proinflammatory cytokines, particularly in response to amyloid-β (Aβ) …

Microglia maintain homeostasis in the central nervous system through phagocytic clearance
of protein aggregates and cellular debris. This function deteriorates during ageing and …

Extracellular deposition of amyloid-β as neuritic plaques and intracellular accumulation of
hyperphosphorylated, aggregated tau as neurofibrillary tangles are two of the characteristic …

Myelin is required for the function of neuronal axons in the central nervous system, but the
mechanisms that support myelin health are unclear. Although macrophages in the central …

Alzheimer disease (AD) is a progressive neurodegenerative disorder characterized by
excessive deposition of amyloid-β (Aβ) peptides in the brain. One of the earliest …

The incidence of Alzheimer's disease (AD), the leading cause of dementia, increases rapidly
with age, but why age constitutes the main risk factor is still poorly understood. Brain ageing …

Reactive astrocytes are strongly induced by central nervous system (CNS) injury and
disease, but their role is poorly understood. Here we show that a subtype of reactive …

ALZHEIMER'S disease is the most common cause of progressive intellectual failure1. The
lesions that develop, called senile plaques, are extracellular deposits principally composed …