Dysfunction of the barrier properties of endothelial cells is implicated in a number of vascular
diseases. One of the more prominent problems is the edema of the lungs seen with Adult …

It is well known that sepsis, periods of lung ischemia followed by reperfusion, various
ventilation regimens, elevation of cerebral spinal fluid pressure, and ischemia/reperfusion of …

Pulmonary edema is a common finding in many clinical and experimental conditions and is
often caused by damage to the endothelial layer. In both clinical conditions and animal …

Recent permeability studies comparing endothelial cell phenotypes derived from alveolar
and extra-alveolar vessels have significant implications for interpreting the mechanisms of …

Alterations in endothelial permeability are a hallmark of inflammation as well as the
underlying cause of many clinical syndromes. Quantifying changes in endothelial barrier …

Methods: Human pulmonary artery endothelial cells were used at passages 4-8. Actin
cytoskeleton was examined by immunostaining with Texas Red-labeled phalloidin …

Early studies of fluid transport across the pulmonary epithelium were conducted in intact
animals or isolated lungs. Although the location and cells responsible for transport cannot …

We report the first determination of lung endothelial barrier properties in ischemic,
nonreperfused microvessels. We quantified the endothelial barrier in terms of hydraulic …

It has generally been assumed that movement of fluid between the pulmonary
microvasculature and surrounding tissues is governed by a “Starling” balance of hydrostatic …

Evidence exists for the utility of measures of small-molecule exchange in assessing the
normal and abnormal transport status of the lung vasculature. The evidence for the …