A novel organotypic cortical slice culture model for traumatic brain injury: molecular changes induced by injury and mesenchymal stromal cell secretome treatment
F Pischiutta, H Cavaleiro, E Caruso… - Frontiers in Cellular …, 2023 - frontiersin.org
Traumatic brain injury (TBI) is a major worldwide neurological disorder with no
neuroprotective treatment available. Three-dimensional (3D) in vitro models of brain …
neuroprotective treatment available. Three-dimensional (3D) in vitro models of brain …
[HTML][HTML] Mesenchymal stromal cell secretome for traumatic brain injury: Focus on immunomodulatory action
F Pischiutta, E Caruso, H Cavaleiro, AJ Salgado… - Experimental …, 2022 - Elsevier
The severity and long-term consequences of brain damage in traumatic brain injured (TBI)
patients urgently calls for better neuroprotective/neuroreparative strategies for this …
patients urgently calls for better neuroprotective/neuroreparative strategies for this …
Mesenchymal stromal cell secretome as a therapeutic strategy for traumatic brain injury
SA Muhammad - BioFactors, 2019 - Wiley Online Library
Traumatic brain injury (TBI) is a global health problem that is a common cause of disability
and mortality. Despite the availability of many treatment options, none is capable of restoring …
and mortality. Despite the availability of many treatment options, none is capable of restoring …
Injury‐preconditioning secretome of umbilical cord mesenchymal stem cells amplified the neurogenesis and cognitive recovery after severe traumatic brain injury in …
XY Liu, MG Wei, J Liang, HH Xu… - Journal of …, 2020 - Wiley Online Library
Traumatic brain injury (TBI) is a dominant cause of death and permanent disability
worldwide. Although TBI could significantly increase the proliferation of adult neural stem …
worldwide. Although TBI could significantly increase the proliferation of adult neural stem …
Interactome and reciprocal activation of pathways in topical mesenchymal stem cells and the recipient cerebral cortex following traumatic brain injury
PK Lam, KKW Wang, AWI Lo, CSW Tong… - Scientific reports, 2017 - nature.com
In this study, GFP-MSCs were topically applied to the surface of cerebral cortex within 1 hour
of experimental TBI. No treatment was given to the control group. Three days after topical …
of experimental TBI. No treatment was given to the control group. Three days after topical …
Human mesenchymal stem cell treatment normalizes cortical gene expression after traumatic brain injury
A Darkazalli, C Vied, CD Badger… - Journal of …, 2017 - liebertpub.com
Traumatic brain injury (TBI) results in a progressive disease state with many adverse and
long-term neurological consequences. Mesenchymal stem cells (MSCs) have emerged as a …
long-term neurological consequences. Mesenchymal stem cells (MSCs) have emerged as a …
Mesenchymal stem cell-derived extracellular vesicles as a cell-free therapy for traumatic brain injury via neuroprotection and neurorestoration
Y Xiong, A Mahmood, M Chopp - Neural Regeneration Research, 2024 - journals.lww.com
Traumatic brain injury is a serious and complex neurological condition that affects millions of
people worldwide. Despite significant advancements in the field of medicine, effective …
people worldwide. Despite significant advancements in the field of medicine, effective …
Evaluation of M2-like macrophage enrichment after diffuse traumatic brain injury through transient interleukin-4 expression from engineered mesenchymal stromal …
Background Appropriately modulating inflammation after traumatic brain injury (TBI) may
prevent disabilities for the millions of those inflicted annually. In TBI, cellular mediators of …
prevent disabilities for the millions of those inflicted annually. In TBI, cellular mediators of …
Modeling controlled cortical impact injury in 3D brain‐like tissue cultures
V Liaudanskaya, JY Chung, C Mizzoni… - Advanced …, 2020 - Wiley Online Library
Traumatic brain injury (TBI) survivors suffer long term from mental illness,
neurodegeneration, and neuroinflammation. Studies of 3D tissue models have provided …
neurodegeneration, and neuroinflammation. Studies of 3D tissue models have provided …
Effects of secretome obtained from normoxia-preconditioned human mesenchymal stem cells in traumatic brain injury rats
TJ Chuang, KC Lin, CC Chio, CC Wang… - Journal of Trauma …, 2012 - journals.lww.com
BACKGROUND The aim of the present study was to investigate whether secretome
obtained from normoxia-preconditioned human mesenchymal stem cells causes attenuation …
obtained from normoxia-preconditioned human mesenchymal stem cells causes attenuation …
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