End-to-end computational approach to the design of RNA biosensors for miRNA biomarkers of cervical cancer

PRS Baabu, S Srinivasan, S Nagarajan… - bioRxiv, 2021 - biorxiv.org
Cervical cancer is a global public health subject as it affects women in the reproductive
ages, and accounts for the second largest burden among cancer patients worldwide with an …

[HTML][HTML] End-to-end computational approach to the design of RNA biosensors for detecting miRNA biomarkers of cervical cancer

PRS Baabu, S Srinivasan, S Nagarajan… - Synthetic and Systems …, 2022 - Elsevier
Cervical cancer is a global public health subject as it affects women in the reproductive
ages, and accounts for the second largest burden among cancer patients worldwide with an …

CerviCare: A Point of Care Screening Device for Cervical Precancer

N Bansal, S Firdaus, M Jocić, J Meyer, TC Valdés, J Wu… - 2024 - drum.lib.umd.edu
Cervical cancer remains a significant health burden, especially in regions with limited
access to diagnostic facilities. To combat this, the UMaryland iGEM Team is developing an …

Reconfigurable hybrid interface for molecular marker diagnostics and in-situ reporting

K Ehrhardt, MT Guinn, T Quarton, MQ Zhang… - Biosensors and …, 2015 - Elsevier
Combinations of molecular signals such as transcription factors and microRNAs in cells are
a reliable indicator of multi-gene disorders. A system capable of detecting these conditions …

Identification and validation of a miRNA-based prognostic signature for cervical cancer through an integrated bioinformatics approach

Y Qi, YL Lai, PC Shen, FH Chen, LJ Lin, HH Wu… - Scientific Reports, 2020 - nature.com
Cervical cancer is the fourth most common cancer in women worldwide. Increasing
evidence has shown that miRNAs are related to the progression of cervical cancer …

Decoding competing endogenous RNA networks for cancer biomarker discovery

X Qi, Y Lin, J Chen, B Shen - Briefings in Bioinformatics, 2020 - academic.oup.com
Crosstalk between competing endogenous RNAs (ceRNAs) is mediated by shared
microRNAs (miRNAs) and plays important roles both in normal physiology and …

[PDF][PDF] Aptamer-Based Biosensor Design for Simultaneous Detection of Cervical Cancer-Related MicroRNAs. 2023, 56, x

R Tamaian - 2023 - sciforum.net
This study presents the design of an innovative aptamer-based biosensor for the detection of
circulating microRNAs (miRNAs) associated with cervical cancer development. The selected …

miRNACancerMAP: an integrative web server inferring miRNA regulation network for cancer

Y Tong, B Ru, J Zhang - Bioinformatics, 2018 - academic.oup.com
MicroRNAs play critical roles in oncogenesis by targeting a few key regulators or a large
cohort of genes impinging on downstream signaling pathways. Conversely, miRNA activity …

Single-molecule sensor for high-confidence detection of miRNA

KM Wijesinghe, MA Kanak, JC Harrell, S Dhakal - ACS sensors, 2022 - ACS Publications
MicroRNAs (miRNAs) play a crucial role in regulating gene expression and have been
linked to many diseases. Therefore, sensitive and accurate detection of disease-linked …

Molecular structure and thermodynamic predictions to create highly sensitive microRNA biosensors

NE Larkey, CN Brucks, SS Lansing, SD Le… - Analytica Chimica …, 2016 - Elsevier
Many studies have established microRNAs (miRNAs) as post-transcriptional regulators in a
variety of intracellular molecular processes. Abnormal changes in miRNA have been …