Gastric cancer is one of the most frequent and lethal malignancies worldwide because of
high frequency of metastasis. Tumor cell motility and invasion play fundamental roles in …

The small guanosine triphosphatase (GTPase) Rho and its downstream effector Rho-
associated kinase (ROCK) is one of a key mediator involved in controlling focal adhesions …

Rho family members are known to regulate malignant transformation and motility of cancer
cells, but the clinicopathological significance of RhoC remains unclear yet in the case of …

Background: Recently, the molecular classification of gastric cancer (GC) promotes the
advances of GC patients' precision therapy and prognosis prediction. According to the Asian …

Results RNAi of RhoA inhibited the survival and promoted the apoptotic of AGS cells. RhoA
RNAi caused an obvious decrease of ROCK1 expression but an increase of caspase …

AIM: Intrahepatic extension is the main cause of liver failure and death in hepatocellular
carcinoma patients. The small GTPase Rho and one of its effector molecules ROCK regulate …

Abstract Purpose: The small GTPase RhoA has been implicated in the regulation of cell
morphology, motility, and transformation, but the role of RhoA protein in the carcinogenesis …

Rho-associated coiled-coil kinase (ROCK) is a major downstream effector of the small
GTPase RhoA. The ROCK family, consisting of ROCK1 and ROCK2, plays a central role in …

Rho GTPases are a family of small GTPases, which play an important role in the regulation
of the actin cytoskeleton. Not surprisingly, Rho GTPases are crucial for cell migration and …

Abstract Although Rho family GTPases RhoA, RhoB and RhoC share more than 85% amino
acid sequence identity, they may play distinct roles in tumor progression. RhoA and RhoC …