Background Our objective was to find single nucleotide polymorphisms (SNPs), within
transcriptional pathways of glucose and lipid metabolism, which are related to multiple …

Several candidate gene studies on the metabolic syndrome (MetS) have been conducted.
However, for most single nucleotide polymorphisms (SNPs) no systematic review on their …

OBJECTIVE: Effect modification by obesity or obesity-related phenotypes (eg physical
activity and diet) was observed in some candidate gene studies on lipids. We aimed to …

Metabolic syndrome (MetS) refers to a cluster of metabolic dysregulations, which include
insulin resistance, obesity, atherogenic dyslipidemia and hypertension. The complex …

OBJECTIVE The metabolic syndrome (MetS) is defined as concomitant disorders of lipid and
glucose metabolism, central obesity, and high blood pressure, with an increased risk of type …

Background—Genome-wide association (GWA) studies have identified several susceptibility
loci for metabolic syndrome (MetS) component traits, but have had variable success in …

Heritability estimates of metabolic syndrome traits vary widely across studies. Some studies
have suggested that the contribution of genes may vary with age or sex. We estimated the …

OBJECTIVE: Circulatory metabolites are important biomarkers for many diseases, especially
metabolic disorders. The biological mechanism regulating circulatory levels of metabolites …

Background: As nuclear receptors and transcription factors have an important regulatory
function in adipocyte differentiation and fat storage, genetic variation in these key regulators …

Recent genome-wide association studies have identified multiple loci robustly associated
with plasma lipids, which also contribute to extreme lipid phenotypes. However, these …