Ageing is a major risk factor for the development of many diseases, prominently including
neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark …

Ensuring cellular protein homeostasis, or proteostasis, requires precise control of protein
synthesis, folding, conformational maintenance, and degradation. A complex and adaptive …

The maintenance of the proteome is essential to preserve cell functionality and the ability to
respond and adapt to the changing environment. This is regulated by the proteostasis …

All cells count on precise mechanisms that regulate protein homeostasis to maintain a stable
and functional proteome. Alterations in these fine-tuned mechanisms underlie the …

Accumulation of intracellular damage is an almost universal hallmark of aging. An improved
understanding of the systems that contribute to cellular protein quality control has shed light …

Genetic and environmental factors responsible for numerous neurodegenerative diseases
vary between disorders, yet age remains a universal risk factor. Age-associated decline in …

A characteristic of many neurodegenerative diseases, including Alzheimer's disease (AD),
Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis …

Loss of protein homeostasis (proteostasis) is a common feature of aging and disease that is
characterized by the appearance of nonnative protein aggregates in various tissues. Protein …

Aging cells accumulate damaged and misfolded proteins through a functional decline in
their protein homeostasis (proteostasis) machinery, leading to reduced cellular viability and …

Aging is a complex process regulated by multiple cellular pathways, including the
proteostasis network. The proteostasis network consists of molecular chaperones, stress …