Mitochondria is a powerhouse organelle involved in ATP synthesis, calcium signaling,
reactive oxygen species (ROS) by oxidative stress production, cell cycle arrest via apoptosis …

BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …

The oocyte is the largest cell found in multicellular organisms. Mitochondria, as the energy
factories for cells, are found in high numbers in oocytes, as they provide the energy for …

Mitochondria are double‐membrane‐bound organelles that are responsible for the
generation of most of the cell's energy. Mitochondrial dysfunction has been implicated in …

Mitochondrial dysfunction is one of the hallmarks of aging. Consistently mitochondrial DNA
(mtDNA) copy number and function decline with age in various tissues. There is increasing …

Mitochondria are well known as 'the powerhouses of the cell'. Indeed, their major role is
cellular energy production driven by both mitochondrial and nuclear DNA. Such a feature …

Mitochondria have been implicated as key factors regulating female reproductive processes.
Notable progress has been made in determining the role of mitochondria with respect to …

Mitochondria affect numerous aspects of mammalian reproduction. We investigated whether
the decrease in oocyte quality associated with aging is related to altered mitochondria …

Along with the decline in oocyte quality, numerous defects such as mitochondrial
insufficiency and the increase of mutation and deletion have been reported in oocyte …

The mitochondrial genome passes from one generation to the next by way of the egg's
cytoplasm, so ordinarily an individual's mitochondrial DNA (mtDNA) is entirely derived from …