Progesterone neuroprotection in traumatic CNS injury and motoneuron degeneration

AF De Nicola, F Labombarda, MCG Deniselle… - Frontiers in …, 2009 - Elsevier
Studies on the neuroprotective and promyelinating effects of progesterone in the nervous
system are of great interest due to their potential clinical connotations. In peripheral …

Progesterone neuroprotection in spinal cord trauma involves up-regulation of brain-derived neurotrophic factor in motoneurons

SL Gonzalez, F Labombarda, MCG Deniselle… - The Journal of Steroid …, 2005 - Elsevier
Progesterone (PROG) provides neuroprotection to the injured central and peripheral
nervous system. These effects may be due to regulation of myelin synthesis in glial cells and …

Progesterone treatment of spinal cord injury: effects on receptors, neurotrophins, and myelination

AF De Nicola, SL Gonzalez, F Labombarda… - Journal of molecular …, 2006 - Springer
In addition to its traditional role in reproduction, progesterone (PROG) has demonstrated
neuroprotective and promyelinating effects in lesions of the peripheral and central nervous …

Progesterone: therapeutic opportunities for neuroprotection and myelin repair

M Schumacher, R Guennoun, DG Stein… - Pharmacology & …, 2007 - Elsevier
Progesterone and its metabolites promote the viability of neurons in the brain and spinal
cord. Their neuroprotective effects have been documented in different lesion models …

Neuroprotection by estrogen and progesterone in traumatic brain injury and spinal cord injury

E Brotfain, SE Gruenbaum, M Boyko… - Current …, 2016 - ingentaconnect.com
In recent years there has been a growing body of clinical and laboratory evidence
demonstrating the neuroprotective effects of estrogen and progesterone after traumatic brain …

Basis of progesterone protection in spinal cord neurodegeneration

MCG Deniselle, JJL Costa, SL Gonzalez… - The Journal of steroid …, 2002 - Elsevier
Progesterone neuroprotection has been reported in experimental brain, peripheral nerve
and spinal cord injury. To investigate for a similar role in neurodegeneration, we studied …

Cellular basis for progesterone neuroprotection in the injured spinal cord

F Labombarda, SL Gonzalez… - Journal of …, 2002 - liebertpub.com
Progesterone (PROG) exerts beneficial and neuroprotective effects in the injured central and
peripheral nervous system. In the present work, we examine PROG effects on three …

Progesterone's role in neuroprotection, a review of the evidence

ER Deutsch, TR Espinoza, F Atif, E Woodall, J Kaylor… - Brain research, 2013 - Elsevier
The sex hormone progesterone has been shown to improve outcomes in animal models of a
number of neurologic diseases, including traumatic brain injury, ischemia, spinal cord injury …

Progesterone protective effects in neurodegeneration and neuroinflammation

AF De Nicola, MC Gonzalez Deniselle… - Journal of …, 2013 - Wiley Online Library
Progesterone is a neuroprotective, promyelinating and anti‐inflammatory factor for the
nervous system. Here, we review the effects of progesterone in models of motoneurone …

Neuroprotection by steroids after neurotrauma in organotypic spinal cord cultures: A key role for progesterone receptors and steroidal modulators of GABAA receptors

F Labombarda, AM Ghoumari, P Liere, AF De Nicola… - …, 2013 - Elsevier
Progesterone is neuroprotective after spinal cord injury, however its mechanism of action
remains unexplored. Here we used organotypic spinal cord slice cultures from 3 weeks-old …