Synthesis, in vitro evaluation and molecular docking studies of novel thiophenyl thiazolyl-pyridine hybrids as potential anticancer agents
FO Ashmawy, SM Gomha, MA Abdallah, MEA Zaki… - Molecules, 2023 - mdpi.com
Many literature reports revealed the anticancer activity of pyridine and thiazole derivatives,
especially in lung cancer. Therefore, a new series of thiazolyl pyridines linked with …
especially in lung cancer. Therefore, a new series of thiazolyl pyridines linked with …
Synthesis, molecular docking study, and cytotoxicity evaluation of some novel 1, 3, 4-thiadiazole as well as 1, 3-thiazole derivatives bearing a pyridine moiety
Pyridine, 1, 3, 4-thiadiazole, and 1, 3-thiazole derivatives have various biological activities,
such as antimicrobial, analgesic, anticonvulsant, and antitubercular, as well as other …
such as antimicrobial, analgesic, anticonvulsant, and antitubercular, as well as other …
Design, synthesis, and antiproliferative activities of novel thiazolyl-pyrazole hybrid derivatives
In this study, a series of derivatives of thiazolyl-pyrazole hybrid structures were designed to
search for new heterocyclic compound-based antitumor agents. The designed target …
search for new heterocyclic compound-based antitumor agents. The designed target …
Synthesis, computational chemical study, antiproliferative activity screening, and molecular docking of some thiophene-based oxadiazole, triazole, and thiazolidinone …
AS Elgubbi, EAE El-Helw, AYA Alzahrani… - RSC …, 2024 - pubs.rsc.org
Thiophene-2-carbohydrazide was used in this study to produce some thiophene-containing
oxadiazole, triazole, and thiazolidinone derivatives through reactions with various carbon …
oxadiazole, triazole, and thiazolidinone derivatives through reactions with various carbon …
Design, synthesis, anticancer evaluation, and molecular docking studies of thiazole–pyrimidine linked amide derivatives
A library of new amide-based thiazole–pyrimidines (13a–j) was designed by considering
vital pharmacophoric features of the potential multi-acting anticancer agents. The analogs …
vital pharmacophoric features of the potential multi-acting anticancer agents. The analogs …
Synthesis, and docking studies of novel heterocycles incorporating the indazolylthiazole moiety as antimicrobial and anticancer agents
NTA Dawoud, EM El-Fakharany, AE Abdallah… - Scientific Reports, 2022 - nature.com
The current study was directed toward developing a new series of fused heterocycles
incorporating indazolylthiazole moiety. The newly synthesized compounds were …
incorporating indazolylthiazole moiety. The newly synthesized compounds were …
Design, synthesis and biological evaluation of novel pyrazolo-oxothiazolidine derivatives as antiproliferative agents against human lung cancer cell line A549
S Yakaiah, PSV Kumar, PB Rani, KD Prasad… - Bioorganic & Medicinal …, 2018 - Elsevier
An efficient, one-pot multicomponent reaction of novel pyrazolo-oxothiazolidine derivatives
was achieved by condensation of 1-(benzofuran-2-yl)-3-(substituted-arylprop-2-en-1-ones …
was achieved by condensation of 1-(benzofuran-2-yl)-3-(substituted-arylprop-2-en-1-ones …
Synthesis and molecular docking of some novel thiazoles and thiadiazoles incorporating pyranochromene moiety as potent anticancer agents
SM Gomha, AO Abdelhamid, OM Kandil… - Mini Reviews in …, 2018 - ingentaconnect.com
Background: Chemotherapy has become one of the methods that are being adopted to treat
cancer. Coumarins, thiazoles and thiadiazoles are versatile synthetic scaffolds possessing …
cancer. Coumarins, thiazoles and thiadiazoles are versatile synthetic scaffolds possessing …
Novel thiadiazole-thiazole hybrids: synthesis, molecular docking, and cytotoxicity evaluation against liver cancer cell lines
One of the worst diseases, cancer claims millions of lives each year throughout the world,
necessitating the creation of novel treatments. In this study, we designed a novel series of 1 …
necessitating the creation of novel treatments. In this study, we designed a novel series of 1 …
Novel synthesis of pyran, thiophene, and pyridine derivatives incorporating thiazole ring and their antitumor evaluation
RM Mohareb, EM Khalil, AE Mayhoub… - Journal of …, 2020 - Wiley Online Library
This study aims to design and synthesize a number of novel pyran, thiophene, and pyridine
derivatives incorporating thiazole ring and evaluate their antitumor inhibition (μM) as …
derivatives incorporating thiazole ring and evaluate their antitumor inhibition (μM) as …
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