Synthesis, in vitro evaluation and molecular docking studies of novel thiophenyl thiazolyl-pyridine hybrids as potential anticancer agents

FO Ashmawy, SM Gomha, MA Abdallah, MEA Zaki… - Molecules, 2023 - mdpi.com
Many literature reports revealed the anticancer activity of pyridine and thiazole derivatives,
especially in lung cancer. Therefore, a new series of thiazolyl pyridines linked with …

Synthesis, molecular docking study, and cytotoxicity evaluation of some novel 1, 3, 4-thiadiazole as well as 1, 3-thiazole derivatives bearing a pyridine moiety

AS Abouzied, JY Al-Humaidi, AS Bazaid, H Qanash… - Molecules, 2022 - mdpi.com
Pyridine, 1, 3, 4-thiadiazole, and 1, 3-thiazole derivatives have various biological activities,
such as antimicrobial, analgesic, anticonvulsant, and antitubercular, as well as other …

Design, synthesis, and antiproliferative activities of novel thiazolyl-pyrazole hybrid derivatives

B Kuzu, A Ergüç, F Karakuş, E Arzuk - Medicinal Chemistry Research, 2023 - Springer
In this study, a series of derivatives of thiazolyl-pyrazole hybrid structures were designed to
search for new heterocyclic compound-based antitumor agents. The designed target …

Synthesis, computational chemical study, antiproliferative activity screening, and molecular docking of some thiophene-based oxadiazole, triazole, and thiazolidinone …

AS Elgubbi, EAE El-Helw, AYA Alzahrani… - RSC …, 2024 - pubs.rsc.org
Thiophene-2-carbohydrazide was used in this study to produce some thiophene-containing
oxadiazole, triazole, and thiazolidinone derivatives through reactions with various carbon …

Design, synthesis, anticancer evaluation, and molecular docking studies of thiazole–pyrimidine linked amide derivatives

CM Bandaru, N Poojith, SS Jadav… - Polycyclic Aromatic …, 2022 - Taylor & Francis
A library of new amide-based thiazole–pyrimidines (13a–j) was designed by considering
vital pharmacophoric features of the potential multi-acting anticancer agents. The analogs …

Synthesis, and docking studies of novel heterocycles incorporating the indazolylthiazole moiety as antimicrobial and anticancer agents

NTA Dawoud, EM El-Fakharany, AE Abdallah… - Scientific Reports, 2022 - nature.com
The current study was directed toward developing a new series of fused heterocycles
incorporating indazolylthiazole moiety. The newly synthesized compounds were …

Design, synthesis and biological evaluation of novel pyrazolo-oxothiazolidine derivatives as antiproliferative agents against human lung cancer cell line A549

S Yakaiah, PSV Kumar, PB Rani, KD Prasad… - Bioorganic & Medicinal …, 2018 - Elsevier
An efficient, one-pot multicomponent reaction of novel pyrazolo-oxothiazolidine derivatives
was achieved by condensation of 1-(benzofuran-2-yl)-3-(substituted-arylprop-2-en-1-ones …

Synthesis and molecular docking of some novel thiazoles and thiadiazoles incorporating pyranochromene moiety as potent anticancer agents

SM Gomha, AO Abdelhamid, OM Kandil… - Mini Reviews in …, 2018 - ingentaconnect.com
Background: Chemotherapy has become one of the methods that are being adopted to treat
cancer. Coumarins, thiazoles and thiadiazoles are versatile synthetic scaffolds possessing …

Novel thiadiazole-thiazole hybrids: synthesis, molecular docking, and cytotoxicity evaluation against liver cancer cell lines

GF Aljohani, TZ Abolibda, M Alhilal… - Journal of Taibah …, 2022 - Taylor & Francis
One of the worst diseases, cancer claims millions of lives each year throughout the world,
necessitating the creation of novel treatments. In this study, we designed a novel series of 1 …

Novel synthesis of pyran, thiophene, and pyridine derivatives incorporating thiazole ring and their antitumor evaluation

RM Mohareb, EM Khalil, AE Mayhoub… - Journal of …, 2020 - Wiley Online Library
This study aims to design and synthesize a number of novel pyran, thiophene, and pyridine
derivatives incorporating thiazole ring and evaluate their antitumor inhibition (μM) as …