Severe peanut allergy is driven by B cell-derived, allergen-specific IgE. Early introduction of
peanut proteins into the diet is the only clinically-validated strategy to protect against peanut …

Background Circulating IgE and subsequent severe allergic reactions to peanut are
sustained and propagated by recall of peanut allergen-specific memory B cells. Objectives …

Methods Peanut-allergic donor C3H/HeJ mice (with similar anti-peanut IgE levels, symptom
scores (SS) and temperature drops (dT) following intraperitoneal (IP) challenge with crude …

Methods Siglec-engaging tolerance-inducing antigenic liposomes (STALs) co-displaying
peanut allergens (Ara h 1, 2 or 3) and high-affinity CD22 ligand (CD22L-STALs) were …

Background IgE production against innocuous food antigens can result in anaphylaxis, a
severe life-threatening consequence of allergic reactions. The maintenance of IgE immunity …

Background Peanut allergy (PNA) has been reported to be transferred to tolerant recipients
through organ and bone marrow (BM) transplantation. The roles T and B cells play in …

Food allergy is caused by allergen-specific immunoglobulin E (IgE) antibodies, but little is
known about the B cell memory of persistent IgE responses. Here, we describe, in human …

Rationale It is generally accepted that B cell antibody responses depend upon T cell help
(except for a few T-independent antigens). Nevertheless, a recent study by Bernasconi et al …

Food allergy is caused by allergen-specific IgE antibodies but little is known about the B cell
memory of persistent IgE responses. Here we describe in human pediatric peanut allergy …

Allergy is defined as an inappropriate immune response to a typically innocuous agent.
Many allergic responses are IgE-mediated, wherein allergen-specific IgE antibodies bind …