Quorum-sensing systems as targets for antivirulence therapy

T Defoirdt - Trends in microbiology, 2018 - cell.com
The development of novel therapies to control diseases caused by antibiotic-resistant
pathogens is one of the major challenges we are currently facing. Many important plant …

[HTML][HTML] Development of quorum-based anti-virulence therapeutics targeting Gram-negative bacterial pathogens

SB Tay, WS Yew - International journal of molecular sciences, 2013 - mdpi.com
Quorum sensing is a cell density-dependent signaling phenomenon used by bacteria for
coordination of population-wide phenotypes, such as expression of virulence genes …

Alternative approaches to treat bacterial infections: targeting quorum-sensing

P Piewngam, J Chiou, P Chatterjee… - Expert review of anti …, 2020 - Taylor & Francis
Introduction The emergence of multi-and pan-drug-resistant bacteria represents a global
crisis that calls for the development of alternative anti-infective strategies. These comprise …

Exploiting quorum sensing to confuse bacterial pathogens

B LaSarre, MJ Federle - Microbiology and molecular biology …, 2013 - Am Soc Microbiol
Cell-cell communication, or quorum sensing, is a widespread phenomenon in bacteria that
is used to coordinate gene expression among local populations. Its use by bacterial …

[HTML][HTML] Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections

M Hentzer, M Givskov - The Journal of clinical investigation, 2003 - Am Soc Clin Investig
Traditional treatment of infectious diseases is based on compounds that aim to kill or inhibit
bacterial growth. A major concern with this approach is the frequently observed …

[HTML][HTML] Quorum sensing communication between bacteria and human cells: signals, targets, and functions

A Holm, E Vikström - Frontiers in plant science, 2014 - frontiersin.org
Both direct and long-range interactions between pathogenic Pseudomonas aeruginosa
bacteria and their eukaryotic hosts are important in the outcome of infections. For cell-to-cell …

Quorum-quenching microbial infections: mechanisms and implications

YH Dong, LH Wang, LH Zhang - … transactions of the …, 2007 - royalsocietypublishing.org
The discovery of antibiotics early in the past century marked the beginning of active control
and prevention of infectious microbial diseases. However, extensive use of antibiotics has …

[HTML][HTML] Quorum-sensing regulation of antimicrobial resistance in bacteria

X Zhao, Z Yu, T Ding - Microorganisms, 2020 - mdpi.com
Quorum sensing is a cell-to-cell communication system that exists widely in the microbiome
and is related to cell density. The high-density colony population can generate a sufficient …

Quorum sensing: an emerging target for antibacterial chemotherapy?

P Williams - Expert Opinion on Therapeutic Targets, 2002 - Taylor & Francis
The emergence of bacterial strains exhibiting resistance to multiple antibiotic classes poses
a major threat to medicine and public health. This has been compounded over the last few …

Inhibitors and antagonists of bacterial quorum sensing

N Ni, M Li, J Wang, B Wang - Medicinal research reviews, 2009 - Wiley Online Library
Bacteria can regulate community‐wide behaviors including biofilm formation, virulence,
conjugation, sporulation, and swarming motility through a process called quorum sensing …