Quorum-sensing systems as targets for antivirulence therapy
T Defoirdt - Trends in microbiology, 2018 - cell.com
The development of novel therapies to control diseases caused by antibiotic-resistant
pathogens is one of the major challenges we are currently facing. Many important plant …
pathogens is one of the major challenges we are currently facing. Many important plant …
[HTML][HTML] Development of quorum-based anti-virulence therapeutics targeting Gram-negative bacterial pathogens
SB Tay, WS Yew - International journal of molecular sciences, 2013 - mdpi.com
Quorum sensing is a cell density-dependent signaling phenomenon used by bacteria for
coordination of population-wide phenotypes, such as expression of virulence genes …
coordination of population-wide phenotypes, such as expression of virulence genes …
Alternative approaches to treat bacterial infections: targeting quorum-sensing
P Piewngam, J Chiou, P Chatterjee… - Expert review of anti …, 2020 - Taylor & Francis
Introduction The emergence of multi-and pan-drug-resistant bacteria represents a global
crisis that calls for the development of alternative anti-infective strategies. These comprise …
crisis that calls for the development of alternative anti-infective strategies. These comprise …
Exploiting quorum sensing to confuse bacterial pathogens
B LaSarre, MJ Federle - Microbiology and molecular biology …, 2013 - Am Soc Microbiol
Cell-cell communication, or quorum sensing, is a widespread phenomenon in bacteria that
is used to coordinate gene expression among local populations. Its use by bacterial …
is used to coordinate gene expression among local populations. Its use by bacterial …
[HTML][HTML] Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections
M Hentzer, M Givskov - The Journal of clinical investigation, 2003 - Am Soc Clin Investig
Traditional treatment of infectious diseases is based on compounds that aim to kill or inhibit
bacterial growth. A major concern with this approach is the frequently observed …
bacterial growth. A major concern with this approach is the frequently observed …
[HTML][HTML] Quorum sensing communication between bacteria and human cells: signals, targets, and functions
A Holm, E Vikström - Frontiers in plant science, 2014 - frontiersin.org
Both direct and long-range interactions between pathogenic Pseudomonas aeruginosa
bacteria and their eukaryotic hosts are important in the outcome of infections. For cell-to-cell …
bacteria and their eukaryotic hosts are important in the outcome of infections. For cell-to-cell …
Quorum-quenching microbial infections: mechanisms and implications
The discovery of antibiotics early in the past century marked the beginning of active control
and prevention of infectious microbial diseases. However, extensive use of antibiotics has …
and prevention of infectious microbial diseases. However, extensive use of antibiotics has …
[HTML][HTML] Quorum-sensing regulation of antimicrobial resistance in bacteria
X Zhao, Z Yu, T Ding - Microorganisms, 2020 - mdpi.com
Quorum sensing is a cell-to-cell communication system that exists widely in the microbiome
and is related to cell density. The high-density colony population can generate a sufficient …
and is related to cell density. The high-density colony population can generate a sufficient …
Quorum sensing: an emerging target for antibacterial chemotherapy?
P Williams - Expert Opinion on Therapeutic Targets, 2002 - Taylor & Francis
The emergence of bacterial strains exhibiting resistance to multiple antibiotic classes poses
a major threat to medicine and public health. This has been compounded over the last few …
a major threat to medicine and public health. This has been compounded over the last few …
Inhibitors and antagonists of bacterial quorum sensing
N Ni, M Li, J Wang, B Wang - Medicinal research reviews, 2009 - Wiley Online Library
Bacteria can regulate community‐wide behaviors including biofilm formation, virulence,
conjugation, sporulation, and swarming motility through a process called quorum sensing …
conjugation, sporulation, and swarming motility through a process called quorum sensing …