Cytosolic Ca2+ signals are organized in complex spatial and temporal patterns that underlie
their unique ability to regulate multiple cellular functions. Changes in intracellular Ca2+ …

Ionized calcium (Ca2+) is the most versatile cellular messenger. All cells use Ca2+ signals
to regulate their activities in response to extrinsic and intrinsic stimuli. Alterations in cellular …

Ca 2+ is a ubiquitous intracellular messenger that controls diverse cellular functions but can
become toxic and cause cell death. Selective control of specific targets depends on …

Calcium signals have been implicated in the regulation of many diverse cellular processes.
The problem of how information from extracellular signals is delivered with specificity and …

From molecules, single cells and tissues to whole organisms, our insights into Ca2+
signalling and the corresponding physiological phenomena are growing exponentially …

Intracellular calcium (Ca2+) signals are of prime importance for cellular function and
behavior and are underpinned by a plethora of Ca2+ channels, pumps, transporters, and …

The field of subcellular Ca2+ homeostasis is evolving rapidly. In parallel with improvements
in spatial and temporal resolution of Ca2+ imaging techniques, new methods using the …

Cells rely on the coordinated action of diverse signaling molecules to sense, interpret, and
respond to their highly dynamic external environment. To ensure the specific and robust flow …

Ever since it was shown that maintenance of muscle contraction required the presence of
extracellular Ca2+, evidence has accumulated that Ca2+ plays a crucial role in excitation …

Ca2+ regulates a multitude of cellular processes and does so by partitioning its actions in
space and time. In this review, we discuss how Ca2+ responses are constructed from small …