Herbal plants typically have complex compositions and diverse mechanisms. Among them,
bioactive constituents with relatively high exposure in vivo are likely to exhibit therapeutic …

A resurgence in the use of medical herbs in the Western world, and the co-use of modern
and traditional therapies is becoming more common. Thus there is the potential for both …

Due to the rapidly increasing global interest in the use of herbs, phytomedicines and other
natural products as medical or complementary remedies, concerns about the clinical …

The concurrent use of drugs and herbal products is becoming increasingly prevalent over
the last decade. Several herbal products have been known to modulate cytochrome P450 …

Human cytochrome P450 3A4 (hCYP3A4) is a predominant enzyme to trigger clinically
relevant drug/herb-drug interactions (DDIs or HDIs). Although a number of herbal medicines …

Cytochrome P450 enzymes are the main drug-metabolizing enzyme, and their activity is
influenced by numerous factors, including several plants' constituents. Herbal products …

Seventy-nine injectable herb extractions have been approved by the Chinese Food and
Drug Administration (CFDA) and are frequently administered intravenously for various …

The use of medicinal plants concomitantly with conventional drugs can result in herb–drug
interactions that cause fluctuations in drug bioavailability and consequent therapeutic failure …

In this study, hydroethanolic extracts of 30 top-selling botanicals (herbs) commonly used as
ingredients of herbal dietary supplements in the US were screened for their potential to …

Drug-metabolizing enzymes, particularly the cytochrome P450 (CYP450) monooxygenases,
play a pivotal role in pharmacokinetics. CYP450 enzymes can be affected by various …