Hacking macrophage-associated immunosuppression for regulating glioblastoma angiogenesis
Glioblastoma (GBM) is the most lethal primary adult brain tumor and its pathology is
hallmarked by distorted neovascularization, diffuse tumor-associated macrophage …
hallmarked by distorted neovascularization, diffuse tumor-associated macrophage …
Rapid 3D bioprinting of glioblastoma model mimicking native biophysical heterogeneity
Glioblastoma multiforme (GBM) is the most lethal primary brain tumor characterized by high
cellular and molecular heterogeneity, hypervascularization, and innate drug resistance …
cellular and molecular heterogeneity, hypervascularization, and innate drug resistance …
Engineering strategies to mimic the glioblastoma microenvironment
Glioblastoma multiforme (GBM) is the most common and deadly brain tumor, with a mean
survival time of only 21 months. Despite the dramatic improvements in our understanding of …
survival time of only 21 months. Despite the dramatic improvements in our understanding of …
A three-dimensional (3D) organotypic microfluidic model for glioma stem cells–Vascular interactions
Glioblastoma (GBM) is one of the deadliest forms of cancer. Despite many treatment options,
prognosis of GBM remains dismal with a 5-year survival rate of 4.7%. Even then, tumors …
prognosis of GBM remains dismal with a 5-year survival rate of 4.7%. Even then, tumors …
[HTML][HTML] Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity
A Chryplewicz, J Scotton, M Tichet, A Zomer, K Shchors… - Cancer Cell, 2022 - cell.com
Glioblastoma (GBM) is poorly responsive to therapy and invariably lethal. One conceivable
strategy to circumvent this intractability is to co-target distinctive mechanistic components of …
strategy to circumvent this intractability is to co-target distinctive mechanistic components of …
Triculture model of in vitro BBB and its application to study BBB‐associated chemosensitivity and drug delivery in glioblastoma
Physiologically, brain tumors interact with surrounding vascular and glial cells, and change
their responses to survive in brain tissue‐specific microenvironments. A major difficulty in …
their responses to survive in brain tissue‐specific microenvironments. A major difficulty in …
Targeted inducible delivery of immunoactivating cytokines reprograms glioblastoma microenvironment and inhibits growth in mouse models
Glioblastoma multiforme (GBM) is the most common and lethal brain tumor characterized by
a strongly immunosuppressive tumor microenvironment (TME) that represents a barrier also …
a strongly immunosuppressive tumor microenvironment (TME) that represents a barrier also …
Perivascular signals alter global gene expression profile of glioblastoma and response to temozolomide in a gelatin hydrogel
MT Ngo, BAC Harley - Biomaterials, 2019 - Elsevier
Glioblastoma (GBM) is the most common primary malignant brain tumor, with patients
exhibiting poor survival (median survival time: 15 months). Difficulties in treating GBM …
exhibiting poor survival (median survival time: 15 months). Difficulties in treating GBM …
3D‐bioprinted mini‐brain: a glioblastoma model to study cellular interactions and therapeutics
Glioblastoma‐associated macrophages (GAMs) play a crucial role in the progression and
invasiveness of glioblastoma multiforme (GBM); however, the exact crosstalk between GAMs …
invasiveness of glioblastoma multiforme (GBM); however, the exact crosstalk between GAMs …
[HTML][HTML] Inflammatory mediators in glioma microenvironment play a dual role in gliomagenesis and mesenchymal stem cell homing: implication for cellular therapy
Glioblastoma is the most aggressive malignant primary brain tumor, with a dismal prognosis
and a devastating overall survival. Despite aggressive surgical resection and adjuvant …
and a devastating overall survival. Despite aggressive surgical resection and adjuvant …