Abstract Hyper Immunoglobulin M syndrome (HIGM) is a rare primary immunodeficiency
disorder characterized by low or absent levels of serum IgG, IgA, IgE and normal or …

Abstract Purpose The United States Immunodeficiency Network (USIDNET) patient registry
was used to characterize the presentation, genetics, phenotypes, and treatment of patients …

The hyper IgM syndromes are a group of rare inherited immune deficiency disorders
characterized by impairment of immunoglobulin isotype switching resulting from defects in …

Abstract Introduction Immunodeficiency with hyper-IgM (HIGM) results from genetic defects
in the CD40–CD40 ligand (CD40L) pathway or in the enzymes required for immunoglobulin …

Hyper-IgM (HIGM) syndrome is a heterogeneous group of disorders characterized by normal
or elevated serum IgM levels associated with absent or decreased IgG, IgA and IgE. Here …

Abstract Background Hyper-immunoglobulin M (HIGM) syndromes are a heterogeneous
group of primary immunodeficiency disorders, characterized by recurrent infections …

Immunodeficiency with hyper-IgM (HIM) is a rare disorder characterized by recurrent
infections associated with low IgG and IgA, and normal to increased IgM serum levels. Both …

The primary immunodeficiency (PID) diseases comprise a heterogeneous group of inherited
disorders of immune function. Technical advancements in whole-genome, whole-exome …

X‐linked hyper‐IgM syndrome (XHIM), or hyper‐IgM syndrome type 1 (HIGM1), is a rare
primary immunodeficiency disorder susceptible to recurrent bacterial infection and …

Abstract Purpose Hyper-IgM syndrome due to CD40 deficiency (HIGM3) is a rare form of
primary immunodeficiency with few reported cases. In this study, we further characterize the …