The population pharmacokinetics of tafenoquine were studied in Australian soldiers taking
tafenoquine for malarial prophylaxis. The subjects (476 males and 14 females) received a …

Aims To describe the population pharmacokinetics of tafenoquine in healthy volunteers after
receiving tafenoquine for malaria prophylaxis. Methods The population consisted of 135 …

ABSTRACT Tafenoquine (TQ), a new 8-aminoquinoline with activity against all stages of the
Plasmodium vivax life cycle, is being developed for the radical cure of acute P. vivax malaria …

We measured plasma tafenoquine concentrations in Thai soldiers given a monthly regimen
of tafenoquine to determine whether these concentrations adequately suppressed malarial …

Tafenoquine is a novel 8-aminoquinoline antimalarial drug recently approved by the US
Food and Drug Administration (FDA) for the radical cure of acute Plasmodium vivax malaria …

This study represents the first phase III trial of the safety, tolerability, and effectiveness of
tafenoquine for malaria prophylaxis. In a randomized (3: 1), double-blinded study, Australian …

Objective The purpose of this study was to determine the population pharmacokinetics of
mefloquine in healthy military personnel during prophylaxis for malaria infections. Methods …

Tafenoquine is in development as a single-dose treatment for relapse prevention in
individuals with Plasmodium vivax malaria. Tafenoquine must be coadministered with a …

Background Tafenoquine is an analogue of primaquine with an improved therapeutic and
safety profile. It has a long half-life and activity against liver-stage malaria parasites, so may …

Background Tafenoquine is a new prophylactic antimalarial drug. The current analysis
presents an integrated safety assessment of the Tafenoquine Anticipated Clinical Regimen …