Microglia originate from myeloid progenitors in the embryonic yolk sac and play an integral
role in central nervous system (CNS) development, immune surveillance and repair. The …

Multiple Sclerosis (MS) is a neurodegenerative disease characterized by multiple focal
lesions, ongoing demyelination and, for most people, a lack of remyelination. MS lesions are …

Microglia are the resident macrophages of the central nervous system (CNS). They have
important physiological functions in maintaining tissue homeostasis but also contribute to …

Microglia are the resident immune cells that constantly survey the central nervous system.
They can adapt to their environment and respond to injury or insult by altering their …

Therapeutically controlling chronic progression in multiple sclerosis (MS) remains a major
challenge. MS progression is defined as a steady loss of parenchymal and functional …

Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous
system (CNS) in the Western world. The disease is characterized histologically by the …

Microglia are resident immune cells that play multiple roles in central nervous system (CNS)
development and disease. Although the classical concept of microglia/macrophage …

Along with microglia and monocyte-derived macrophages, macrophages in the perivascular
space, choroid plexus, and meninges are the principal effector cells in neuroinflammatory …

Despite the development of highly effective treatments for relapsing–remitting multiple
sclerosis (MS), limited progress has been made in addressing primary progressive or …

As resident macrophages of the CNS, microglia are critical immune effectors of inflammatory
lesions and associated neural dysfunctions. In multiple sclerosis (MS) and its animal …