Infertility has become a major health issue in the world. It affects the social life of couples
and of all infertility cases; approximately 40–50% is due to “male factor” infertility. Male …

Reproductive biology is a uniquely important topic since it is about germ cells, which are
central for transmitting genetic information from generation to generation. In this review, we …

Spermatogenesis involves precise temporal and spatial gene expression and cell signalling
to reach a coordinated balance between self-renewal and differentiation of spermatogonial …

BACKGROUND Subfertility affects approximately 15% of all couples, and a severe male
factor is identified in 17% of these couples. While the etiology of a severe male factor …

Reconstitution in culture of biological processes, such as differentiation and organization, is
a key challenge in regenerative medicine, and one in which stem cell technology plays a …

Spermatogonial stem cells (SSCs) are the only adult stem cells capable of passing genes
onto the next generation. SSCs also have the potential to provide important knowledge …

Recent developments in stem cell technologies have made significant advancements in the
field of in vitro gametogenesis. In vitro gametogenesis (IVG) is a promising technology …

Men's reproductive health exclusively depends on the appropriate maturation of certain
germ cells known as sperm. Certain illnesses, such as Klinefelter syndrome, cryptorchidism …

Male infertility affects 7% of the male population, and 10% of infertile men are azoospermic.
In these instances, using microsurgical testicular sperm extraction (m-TESE) and intra …

In vitro generation of functional gametes is a promising approach for treating infertility,
although faithful replication of meiosis has proven to be a substantial obstacle to deriving …